Literature DB >> 4024660

Excretion and metabolism of di(2-ethylhexyl)phthalate in man.

P Schmid, C Schlatter.   

Abstract

Di-(2-ethylhexyl)phthalate (DEHP) taken orally by two volunteers (30 mg each) was excreted in the urine to the extent of 11 and 15% of dose. After enzymic hydrolysis the urinary metabolites (derivatives of mono (2-ethylhexyl)phthalate) were methylated and identified by g.l.c.-mass spectrometry (C.I.), and the quantitative distribution of conjugated and free metabolites determined. DEHP taken by the same volunteers over a period of four days at doses of 10 mg daily gave no evidence of accumulation; 15 and 25% of the total dose was recovered in the urine.

Entities:  

Mesh：

Substances：

Year:  1985        PMID： 4024660     DOI： 10.3109/00498258509045356

Source DB:  PubMed          Journal:  Xenobiotica        ISSN： 0049-8254            Impact factor:   1.908


  18 in total

1.  Exposure assessment of phthalate esters in Japanese pregnant women by using urinary metabolite analysis.

Authors:  Yayoi Suzuki; Mayu Niwa; Jun Yoshinaga; Chiho Watanabe; Yoshifumi Mizumoto; Shigeko Serizawa; Hiroaki Shiraishi
Journal:  Environ Health Prev Med       Date:  2009-02-18       Impact factor: 3.674

2.  Early life exposure to phthalates in the Canadian Healthy Infant Longitudinal Development (CHILD) study: a multi-city birth cohort.

Authors:  Garthika Navaranjan; Tim K Takaro; Amanda J Wheeler; Miriam L Diamond; Huan Shu; Meghan B Azad; Allan B Becker; Ruixue Dai; Shelley A Harris; Diana L Lefebvre; Zihang Lu; Piush J Mandhane; Kathleen McLean; Theo J Moraes; James A Scott; Stuart E Turvey; Malcolm R Sears; Padmaja Subbarao; Jeffrey R Brook
Journal:  J Expo Sci Environ Epidemiol       Date:  2019-10-22       Impact factor: 5.563

Review 3.  Assessment of phthalates/phthalate alternatives in children's toys and childcare articles: Review of the report including conclusions and recommendation of the Chronic Hazard Advisory Panel of the Consumer Product Safety Commission.

Authors:  Paul J Lioy; Russ Hauser; Chris Gennings; Holger M Koch; Philip E Mirkes; Bernard A Schwetz; Andreas Kortenkamp
Journal:  J Expo Sci Environ Epidemiol       Date:  2015-05-06       Impact factor: 5.563

Review 4.  Modes of action and species-specific effects of di-(2-ethylhexyl)phthalate in the liver.

Authors:  Ivan Rusyn; Jeffrey M Peters; Michael L Cunningham
Journal:  Crit Rev Toxicol       Date:  2006-05       Impact factor: 5.635

5.  Biological monitoring of exposure to di(2-ethylhexyl) phthalate in six French factories: a field study.

Authors:  R Gaudin; P Marsan; S Ndaw; A Robert; P Ducos
Journal:  Int Arch Occup Environ Health       Date:  2010-08-29       Impact factor: 3.015

6.  Biological monitoring of occupational exposure to di(2-ethylhexyl) phthalate: survey of workers exposed to plastisols.

Authors:  R Gaudin; P Marsan; A Robert; P Ducos; A Pruvost; M Lévi; P Bouscaillou
Journal:  Int Arch Occup Environ Health       Date:  2007-12-21       Impact factor: 3.015

7.  Determination of four metabolites of the plasticizer di(2-ethylhexyl)phthalate in human urine samples.

Authors:  H A Dirven; P H van den Broek; F J Jongeneelen
Journal:  Int Arch Occup Environ Health       Date:  1993       Impact factor: 3.015

8.  Metabolites of the plasticizer di(2-ethylhexyl)phthalate in urine samples of workers in polyvinylchloride processing industries.

Authors:  H A Dirven; P H van den Broek; A M Arends; H H Nordkamp; A J de Lepper; P T Henderson; F J Jongeneelen
Journal:  Int Arch Occup Environ Health       Date:  1993       Impact factor: 3.015

9.  Di-(2-ethylhexyl)-phthalate as plasticizer in PVC respiratory tubing systems: indications of hazardous effects on pulmonary function in mechanically ventilated, preterm infants.

Authors:  B Roth; P Herkenrath; H J Lehmann; H D Ohles; H J Hömig; G Benz-Bohm; J Kreuder; A Younossi-Hartenstein
Journal:  Eur J Pediatr       Date:  1988-01       Impact factor: 3.183

10.  Perinatal DEHP exposure induces sex- and tissue-specific DNA methylation changes in both juvenile and adult mice.

Authors:  Siyu Liu; Kai Wang; Laurie K Svoboda; Christine A Rygiel; Kari Neier; Tamara R Jones; Raymond G Cavalcante; Justin A Colacino; Dana C Dolinoy; Maureen A Sartor
Journal:  Environ Epigenet       Date:  2021-05-10
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.