Literature DB >> 4020624

The determination of mean residence time using statistical moments: is it correct?

D O Chanter.   

Abstract

The estimation of mean residence time using statistical moment theory is shown to lead to the true mean residence time only in the case of a concentration-time curve which is a single exponential. In other cases, including the commonly encountered double exponential, there is a systematic error present which can lead to the result being incorrect by as much as a factor of 2. For the case of instantaneous input, an alternative estimation procedure is suggested which gives an estimate much closer to the true mean residence time.

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Year:  1985        PMID： 4020624     DOI： 10.1007/bf01073658

Source DB:  PubMed          Journal:  J Pharmacokinet Biopharm        ISSN： 0090-466X


  3 in total

1.  Theory of the mean absorption time, an adjunct to conventional bioavailability studies.

Authors:  D J Cutler
Journal:  J Pharm Pharmacol       Date:  1978-08       Impact factor: 3.765

2.  Statistical moments in pharmacokinetics.

Authors:  K Yamaoka; T Nakagawa; T Uno
Journal:  J Pharmacokinet Biopharm       Date:  1978-12

3.  The application of statistical moment theory to the evaluation of in vivo dissolution time and absorption time.

Authors:  S Riegelman; P Collier
Journal:  J Pharmacokinet Biopharm       Date:  1980-10
  3 in total
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1.  The relevance of residence time theory to pharmacokinetics.

Authors:  M Weiss
Journal:  Eur J Clin Pharmacol       Date:  1992       Impact factor: 2.953

Review 2.  The phenomenon and rationale of marked dependence of drug concentration on blood sampling site. Implications in pharmacokinetics, pharmacodynamics, toxicology and therapeutics (Part II).

Authors:  W L Chiou
Journal:  Clin Pharmacokinet       Date:  1989-10       Impact factor: 6.447

3.  The effect of buthionine sulphoximine, cimetidine and phenobarbitone on the disposition of amsacrine in the rabbit.

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Journal:  Cancer Chemother Pharmacol       Date:  1986       Impact factor: 3.333

4.  Mean residence time and statistical moments.

Authors:  D O Chanter
Journal:  J Pharmacokinet Biopharm       Date:  1986-08

5.  General treatment of mean residence time, clearance, and volume parameters in linear mammillary models with elimination from any compartment.

Authors:  E Nakashima; L Z Benet
Journal:  J Pharmacokinet Biopharm       Date:  1988-10

6.  The non-compartmental steady-state volume of distribution revisited.

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Journal:  J Pharmacokinet Pharmacodyn       Date:  2020-01-03       Impact factor: 2.745

7.  Mean residence time in the body versus mean residence time in the central compartment.

Authors:  L Z Benet
Journal:  J Pharmacokinet Biopharm       Date:  1985-10

8.  Comments on mean residence time determination.

Authors:  E M Landaw; D Katz
Journal:  J Pharmacokinet Biopharm       Date:  1985-10

9.  The determination of mean residence time using statistical moments: it is correct.

Authors:  W R Gillespie; P Veng-Pedersen
Journal:  J Pharmacokinet Biopharm       Date:  1985-10

10.  In vitro-in vivo studies of the quantitative effect of calcium, multivitamins and milk on single dose ciprofloxacin bioavailability.

Authors:  Baishakhi Dey; Prakash Katakam; Fathi H Assaleh; Babu Rao Chandu; Shanta Kumari Adiki; Analava Mitra
Journal:  J Pharm Anal       Date:  2015-03-10
  10 in total

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