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Literature DB >> 4019569

Effect of oral cholestyramine on the elimination of high-dose methotrexate.

Abstract

The anion exchange resin cholestyramine binds methotrexate (MTX) effectively in vitro. The binding capacity exceeds that of activated charcoal by a factor of 5.4. On two patients undergoing high-dose MTX therapy it is also shown that cholestyramine binds MTX in vivo. This leads to an enhanced non-renal excretion of MTX. Therefore, cholestyramine may be of clinical value in patients who develop renal function impairment whilst undergoing MTX therapy.

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Year: 1985 PMID： 4019569 DOI： 10.1007/bf00402501

Source DB: PubMed Journal: J Cancer Res Clin Oncol ISSN： 0171-5216 Impact factor: 4.553

14 in total

1. Removal of methotrexate by filtration-adsorption using charcoal filters or by hemodialysis.

Authors: I Djerassi; W Ciesielka; J S Kim
Journal: Cancer Treat Rep Date: 1977-07

2. Resin hemoperfusion: a new treatment for acute drug intoxication.

Authors: J L Rosenbaum; M S Kramer; R Raja; C Boreyko
Journal: N Engl J Med Date: 1971-04-15 Impact factor: 91.245

3. The interaction between cholestyramine and drugs.

Authors: D G Gallo; K R Bailey; A L Sheffner
Journal: Proc Soc Exp Biol Med Date: 1965-10

4. Methotrexate enteropathy.

Authors: G M Baird; J F Dossetor
Journal: Lancet Date: 1981-01-17 Impact factor: 79.321

5. Pharmacokinetics of high-dose methotrexate with citrovorum factor rescue.

Authors: W H Isacoff; P F Morrison; J Aroesty; K L Willis; J B Block; T L Lincoln
Journal: Cancer Treat Rep Date: 1977-12

6. Rapid plasma clearance and reduced rate and extent of urinary elimination of parenterally administered methotrexate as a result of severe vomiting and diarrhoea.

Authors: H W Van Den Berg; R F Murphy; D G Kennedy
Journal: Cancer Chemother Pharmacol Date: 1980 Impact factor: 3.333

Effect of oral cholestyramine on the elimination of high-dose methotrexate.

1. Removal of methotrexate by filtration-adsorption using charcoal filters or by hemodialysis.

2. Resin hemoperfusion: a new treatment for acute drug intoxication.

3. The interaction between cholestyramine and drugs.

4. Methotrexate enteropathy.

5. Pharmacokinetics of high-dose methotrexate with citrovorum factor rescue.

6. Rapid plasma clearance and reduced rate and extent of urinary elimination of parenterally administered methotrexate as a result of severe vomiting and diarrhoea.

7. Pharmacokinetics of methotrexate and 7-hydroxymethotrexate following infusions of high-dose methotrexate.

8. Pharmacokinetics of sustained serum methotrexate concentrations secondary to gastrointestinal obstruction.

9. Acceleration of the body clearance of phenobarbital by oral activated charcoal.

10. Determination of 7-hydroxymethotrexate in human plasma by reversed phase high-performance liquid chromatography.

1. Survival after unexpected high serum methotrexate concentrations in a patient with osteogenic sarcoma.

Review 2. Clinically important drug interactions with disease-modifying antirheumatic drugs.