| Literature DB >> 3456549 |
R Erttmann, S Bielack, G Landbeck.
Abstract
A rapid and sensitive reversed phase HPLC method was developed for the detection of 7-hydroxymethotrexate (7-OHMTX) which is the main metabolite in human plasma after high-dose methotrexate (MTX) therapy. The simple clean-up procedure of plasma samples described allows the measurement of 7-OHMTX during clinical management of MTX infusions. Elimination kinetics of 7-OHMTX are given from 53 drug cycles of 6 patients.Entities:
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Year: 1986 PMID： 3456549 DOI： 10.1159/000226340
Source DB: PubMed Journal: Oncology ISSN： 0030-2414 Impact factor: 2.935