Literature DB >> 4018256

5-Fluoroorotate: a new liposome-dependent cytotoxic agent.

T D Heath, N G Lopez, W H Stern, D Papahadjopoulos.   

Abstract

The potency of 5-fluoroorotate for inhibition of L929 or CV1-P cell growth is increased by encapsulation in negatively charged liposomes. The optimal liposome composition is dipalmitoylphosphatidylglycerol: cholesterol, 67:33. Unextruded large unilamellar liposomes are the optimal size for delivery. This compound is the second transport-negative drug which we have found to exhibit liposome-dependent delivery.

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Year:  1985        PMID： 4018256     DOI： 10.1016/0014-5793(85)81217-5

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  6 in total

1.  Anti-tumor activity of liposome encapsulated fluoroorotic acid as a single agent and in combination with liposome irinotecan.

Authors:  Kareen Riviere; Heidi M Kieler-Ferguson; Katherine Jerger; Francis C Szoka
Journal:  J Control Release       Date:  2011-05-07       Impact factor: 9.776

2.  The use of a liposome-encapsulated 5-fluoroorotate for glaucoma surgery: I. Animal studies.

Authors:  J A Alvarado
Journal:  Trans Am Ophthalmol Soc       Date:  1989

3.  Increased efficacy of phosphonoformate and phosphonoacetate inhibition of herpes simplex virus type 2 replication by encapsulation in liposomes.

Authors:  F C Szoka; C J Chu
Journal:  Antimicrob Agents Chemother       Date:  1988-06       Impact factor: 5.191

4.  Modulation of human ovarian tumor cell sensitivity to N-(phosphonacetyl)-L-aspartate (PALA) by liposome drug carriers.

Authors:  A Sharma; N L Straubinger; R M Straubinger
Journal:  Pharm Res       Date:  1993-10       Impact factor: 4.200

5.  Application of pharmacokinetic and pharmacodynamic analysis to the development of liposomal formulations for oncology.

Authors:  Sihem Ait-Oudhia; Donald E Mager; Robert M Straubinger
Journal:  Pharmaceutics       Date:  2014-03-18       Impact factor: 6.321

6.  UDP-galactose 4'-epimerase from the liver fluke, Fasciola hepatica: biochemical characterization of the enzyme and identification of inhibitors.

Authors:  Veronika L Zinsser; Steffen Lindert; Samantha Banford; Elizabeth M Hoey; Alan Trudgett; David J Timson
Journal:  Parasitology       Date:  2014-08-15       Impact factor: 3.234
  6 in total

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