Literature DB >> 4016770

Promotion of daunorubicin uptake and toxicity by the calcium antagonist tiapamil and its analogs.

D Kessel, C Wilberding.   

Abstract

Studies were performed with the anthracycline-responsive P388 murine leukemia cell line, and with P388/ADR, a subline selected for doxorubicin resistance. In the P388/ADR cell line, the observed 100-fold daunorubicin resistance is associated with an outward drug transport system which can be inhibited by several calcium antagonists, eg, verapamil and nifedipine. An examination of compounds related to tiapamil, a verapamil analog, has identified a structure which is tenfold more effective than verapamil at potentiating anthracycline accumulation and responsiveness in P388/ADR cells. At no nontoxic level of any calcium antagonist examined was it possible to wholly reverse the degree of daunorubicin resistance found in the P388/ADR cell line.

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Year:  1985        PMID： 4016770

Source DB:  PubMed          Journal:  Cancer Treat Rep        ISSN： 0361-5960


  10 in total

1.  The effects of verapamil and a tiapamil analogue, DMDP, on adriamycin-induced cytotoxicity in P388 adriamycin-resistant and -sensitive leukemia in vitro and in vivo.

Authors:  S Radel; I Bankusli; E Mayhew; Y M Rustum
Journal:  Cancer Chemother Pharmacol       Date:  1988       Impact factor: 3.333

2.  Relationship between cytotoxicity, drug accumulation, DNA damage and repair of human ovarian cancer cells treated with doxorubicin: modulation by the tiapamil analog RO11-2933.

Authors:  M A Alaoui Jamali; M B Yin; A Mazzoni; I Bankusli; Y M Rustum
Journal:  Cancer Chemother Pharmacol       Date:  1989       Impact factor: 3.333

3.  Selective interactions of verapamil with anthraquinones in adriamycin-sensitive and -resistant murine and human tumour cell lines in vitro.

Authors:  E M Gibby; O Boyse; B T Hill
Journal:  Cancer Chemother Pharmacol       Date:  1987       Impact factor: 3.333

4.  Effects of 5,8-dideazaisopteroylglutamate (IAHQ) on L1210 leukemia in mice when given alone and in combination with methotrexate, probenecid, or verapamil.

Authors:  J B Hynes; A B Smith; G R Gale
Journal:  Cancer Chemother Pharmacol       Date:  1986       Impact factor: 3.333

Review 5.  Pharmacologic circumvention of multidrug resistance.

Authors:  J M Ford; W N Hait
Journal:  Cytotechnology       Date:  1993       Impact factor: 2.058

6.  Cyclosporin A reverses vincristine and daunorubicin resistance in acute lymphatic leukemia in vitro.

Authors:  L M Slater; P Sweet; M Stupecky; S Gupta
Journal:  J Clin Invest       Date:  1986-04       Impact factor: 14.808

7.  Epithelial secretion of vinblastine by human intestinal adenocarcinoma cell (HCT-8 and T84) layers expressing P-glycoprotein.

Authors:  J Hunter; B H Hirst; N L Simmons
Journal:  Br J Cancer       Date:  1991-09       Impact factor: 7.640

8.  Retention of activity by selected anthracyclines in a multidrug resistant human large cell lung carcinoma line without P-glycoprotein hyperexpression.

Authors:  H M Coley; P Workman; P R Twentyman
Journal:  Br J Cancer       Date:  1991-03       Impact factor: 7.640

Review 9.  P-glycoprotein inhibitors of natural origin as potential tumor chemo-sensitizers: A review.

Authors:  Hossam M Abdallah; Ahmed M Al-Abd; Riham Salah El-Dine; Ali M El-Halawany
Journal:  J Adv Res       Date:  2014-12-01       Impact factor: 10.479

10.  Cyclosporin A corrects daunorubicin resistance in Ehrlich ascites carcinoma.

Authors:  L M Slater; P Sweet; M Stupecky; M W Wetzel; S Gupta
Journal:  Br J Cancer       Date:  1986-08       Impact factor: 7.640
  10 in total

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