Literature DB >> 3621454

Selective interactions of verapamil with anthraquinones in adriamycin-sensitive and -resistant murine and human tumour cell lines in vitro.

E M Gibby, O Boyse, B T Hill.   

Abstract

Enhancement of the cytotoxicity of adriamycin (ADR) by addition of verpamil (VPM) was selective and, in part, concentration-dependent. In an ADR-resistant murine L5178Y lymphoma subline sensitivity was improved with ADR and 1 microM VPM, whereas the cytotoxic effects of mitoxantrone or esorubicin were not affected by VPM. In human ovarian SK-OV-3 tumour cells ADR cytotoxicity was only enhanced by 6.6 microM VPM and there was no selective advantage against an ADR-resistant subline. Circumvention of ADR resistance by VPM is not a universal phenomenon, appearing least effective against sublines expressing relatively low orders of resistance, which may be those most commonly encountered clinically.

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Year:  1987        PMID： 3621454     DOI： 10.1007/bf00252950

Source DB:  PubMed          Journal:  Cancer Chemother Pharmacol        ISSN： 0344-5704            Impact factor:   3.333


  11 in total

1.  The value of adriamycin in overcoming resistance to methotrexate in tissue culture.

Authors:  B T Hill; L A Price; J H Goldies
Journal:  Eur J Cancer       Date:  1976-07       Impact factor: 9.162

2.  Identification of anthracycline analogues with enhanced cytotoxicity and lack of cross-resistance to adriamycin using a series of mammalian cell lines in vitro.

Authors:  B T Hill; L Y Dennis; X T Li; R D Whelan
Journal:  Cancer Chemother Pharmacol       Date:  1985       Impact factor: 3.333

3.  Absence of HeLa cell contamination in 169 cell lines derived from human tumors.

Authors:  J Fogh; W C Wright; J D Loveless
Journal:  J Natl Cancer Inst       Date:  1977-02       Impact factor: 13.506

4.  Potentiation of antitumor agents by calcium channel blockers with special reference to cross-resistance patterns.

Authors:  T Tsuruo; H Kawabata; N Nagumo; H Iida; Y Kitatani; S Tsukagoshi; Y Sakurai
Journal:  Cancer Chemother Pharmacol       Date:  1985       Impact factor: 3.333

5.  Promotion of daunorubicin uptake and toxicity by the calcium antagonist tiapamil and its analogs.

Authors:  D Kessel; C Wilberding
Journal:  Cancer Treat Rep       Date:  1985-06

6.  Reversal of adriamycin resistance by verapamil in human ovarian cancer.

Authors:  A M Rogan; T C Hamilton; R C Young; R W Klecker; R F Ozols
Journal:  Science       Date:  1984-06-01       Impact factor: 47.728

7.  Establishment of Vincristine-resistant and vindesine-resistant lines of murine lymphoblasts in vitro and characterisation of their patterns of cross-resistance and drug sensitivities.

Authors:  B T Hill; R D Whelan
Journal:  Cancer Chemother Pharmacol       Date:  1982       Impact factor: 3.333

Review 8.  Reversal of acquired resistance to vinca alkaloids and anthracycline antibiotics.

Authors:  T Tsuruo
Journal:  Cancer Treat Rep       Date:  1983-10

9.  Resistance of human glioma to adriamycin in vitro: the role of membrane transport and its circumvention with verapamil.

Authors:  S Merry; C A Fetherston; S B Kaye; R I Freshney; J A Plumb
Journal:  Br J Cancer       Date:  1986-01       Impact factor: 7.640

10.  Growth of human tumour cell colonies from biopsies using two soft-agar techniques.

Authors:  V D Courtenay; P J Selby; I E Smith; J Mills; M J Peckham
Journal:  Br J Cancer       Date:  1978-07       Impact factor: 7.640
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  4 in total

1.  Effects of verapamil enantiomers and major metabolites on the cytotoxicity of vincristine and daunomycin in human lymphoma cell lines.

Authors:  K Häussermann; B Benz; V Gekeler; K Schumacher; M Eichelbaum
Journal:  Eur J Clin Pharmacol       Date:  1991       Impact factor: 2.953

Review 2.  Mitoxantrone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in the chemotherapy of cancer.

Authors:  D Faulds; J A Balfour; P Chrisp; H D Langtry
Journal:  Drugs       Date:  1991-03       Impact factor: 9.546

3.  Identification of anthracyclines and related agents that retain preferential activity over adriamycin in multidrug-resistant cell lines, and further resistance modification by verapamil and cyclosporin A.

Authors:  H M Coley; P R Twentyman; P Workman
Journal:  Cancer Chemother Pharmacol       Date:  1989       Impact factor: 3.333

4.  Comparative effectiveness of mitoxantrone and doxorubicin in overcoming experimentally induced drug resistance in murine and human tumour cell lines in vitro.

Authors:  B T Hill; L K Hosking; S A Shellard; R D Whelan
Journal:  Cancer Chemother Pharmacol       Date:  1989       Impact factor: 3.333
  4 in total

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