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Literature DB >> 401463

Localization and characterization of phenylethanolamine N-methyl transferase in the brain of various mammalian species.

J Y Lew, Y Matsumoto, J Pearson, M Goldstein, T Hökfelt, K Fuxe.

Abstract

The distribution of PNMT activity in various regions and nuclei of the rat, monkey and human brain was investigated. The distribution of PNMT activity in the rat brain correlates with the distribution of PNMT immunofluorescence. The PNMT activity in the primate brain is more widely distributed than in the rat brain. High and intermediate enzyme activity values were dound in the same regions of the primate brain as in the rat brain. Intermediate or low levels were also found in various other regions of the primate brain, e.g., basal ganglia, amygdala, septum, habenula. The brain PNMT has the same substrate specificity and similar kinetic properties as the adrenal enzyme. Immunotitration studies revealed cross-reactivity between the homologous adrenal and brain PNMT.

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Year: 1977 PMID： 401463 DOI： 10.1016/0006-8993(77)90100-7

Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252

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Cited

14 in total

1. Ultrastructure of adrenaline-synthesizing group-A1 neurons in the rat brain under normal and emotionally stressful conditions.

Authors: B A Zhigadlo; T I Belova
Journal: Neurosci Behav Physiol Date: 1982 Sep-Oct

2. Phenylethanolamine N-methyltransferase from the brain and adrenal medulla of the rat: a comparison of their properties.

Authors: P H Yu
Journal: Neurochem Res Date: 1978-12 Impact factor: 3.996

3. Studies on the characterization and inhibition of rat brain phenylethanolamine N-methyltransferase.

Authors: R G Pendleton; J Khalsa; G Gessner; J Sawyer
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1977-10 Impact factor: 3.000

4. Activation in young rats induced by LY134046, an inhibitor of phenylethanolamine N-methyltransferase.

Authors: I N Mefford; A L Lawrenz; J K Hsiao; J N Crawley
Journal: Psychopharmacology (Berl) Date: 1989 Impact factor: 4.530

5. Early biochemical and morphological changes of the rat adrenal medulla induced by xylitol.

Authors: U A Boelsterli; G Zbinden
Journal: Arch Toxicol Date: 1985-04 Impact factor: 5.153

6. Differences in the immunoreactivity to phenylethanolamine-N-methyltransferase in the central adrenergic neurons of four strains of rats.

Authors: G Alonso; S Gaillet
Journal: Cell Tissue Res Date: 1991-08 Impact factor: 5.249

Localization and characterization of phenylethanolamine N-methyl transferase in the brain of various mammalian species.

1. Ultrastructure of adrenaline-synthesizing group-A1 neurons in the rat brain under normal and emotionally stressful conditions.

2. Phenylethanolamine N-methyltransferase from the brain and adrenal medulla of the rat: a comparison of their properties.

3. Studies on the characterization and inhibition of rat brain phenylethanolamine N-methyltransferase.

4. Activation in young rats induced by LY134046, an inhibitor of phenylethanolamine N-methyltransferase.

5. Early biochemical and morphological changes of the rat adrenal medulla induced by xylitol.

6. Differences in the immunoreactivity to phenylethanolamine-N-methyltransferase in the central adrenergic neurons of four strains of rats.

7. Catecholamines and serotonin in the rat central nervous system after 6-OHDA, 5-7-DHT and p-CPA.

8. The adrenochrome hypothesis of schizophrenia revisited.

9. Impaired conditioned fear response and startle reactivity in epinephrine-deficient mice.

10. Increase in noradrenaline-synthesizing enzyme activity in medulla oblongata in Parkinson's disease.