Literature DB >> 4011429

Analysis of the promoter region and the N-propeptide domain of the human pro alpha 2(I) collagen gene.

L A Dickson, W de Wet, M Di Liberto, D Weil, F Ramirez.   

Abstract

We have located the exon coding for the start site of transcription of the human pro alpha 2(I) collagen gene. Comparison with the homologous region of other fibrillar collagen genes has confirmed the existence of a consensus sequence (CATGTCTA-n-TAGACATG) capable of forming a hairpin secondary structure possibly involved in the regulation of collagen biosynthesis. Sequence comparison of the chromosomal regions at the 5' end of the pro alpha 1(I) and pro alpha 2(I) collagen genes failed to identify unique DNA elements potentially mediating common regulatory signals. Sequencing of four exons coding for the N-terminal propeptide has determined most of its structure and it has implied the existence of smaller coding units similar to the 11 and 18 bp exons originally described in the avian gene.

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Year:  1985        PMID： 4011429      PMCID： PMC341250          DOI： 10.1093/nar/13.10.3427

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  20 in total

1.  Levels of translatable mRNAs for cell surface protein, collagen precursors, and two membrane proteins are altered in Rous sarcoma virus-transformed chick embryo fibroblasts.

Authors:  S L Adams; M E Sobel; B H Howard; K Olden; K M Yamada; B de Crombrugghe; I Pastan
Journal:  Proc Natl Acad Sci U S A       Date:  1977-08       Impact factor: 11.205

2.  Spliced early mRNAs of simian virus 40.

Authors:  A J Berk; P A Sharp
Journal:  Proc Natl Acad Sci U S A       Date:  1978-03       Impact factor: 11.205

3.  A new method for sequencing DNA.

Authors:  A M Maxam; W Gilbert
Journal:  Proc Natl Acad Sci U S A       Date:  1977-02       Impact factor: 11.205

Review 4.  Structurally distinct collagen types.

Authors:  P Bornstein; H Sage
Journal:  Annu Rev Biochem       Date:  1980       Impact factor: 23.643

5.  Analysis of the 3' end of the human pro-alpha 2(I) collagen gene. Utilization of multiple polyadenylation sites in cultured fibroblasts.

Authors:  J C Myers; L A Dickson; W J de Wet; M P Bernard; M L Chu; M Di Liberto; G Pepe; F O Sangiorgi; F Ramirez
Journal:  J Biol Chem       Date:  1983-08-25       Impact factor: 5.157

6.  Enhanced graphic matrix analysis of nucleic acid and protein sequences.

Authors:  J V Maizel; R P Lenk
Journal:  Proc Natl Acad Sci U S A       Date:  1981-12       Impact factor: 11.205

7.  Synthesis of a shortened pro-alpha 2(I) chain and decreased synthesis of pro-alpha 2(I) chains in a proband with osteogenesis imperfecta.

Authors:  W J de Wet; T Pihlajaniemi; J Myers; T E Kelly; D J Prockop
Journal:  J Biol Chem       Date:  1983-06-25       Impact factor: 5.157

8.  Structure of the promoter for chicken alpha 2 type I collagen gene.

Authors:  G Vogeli; H Ohkubo; M E Sobel; Y Yamada; I Pastan; B de Crombrugghe
Journal:  Proc Natl Acad Sci U S A       Date:  1981-09       Impact factor: 11.205

9.  Chick pro alpha 2 (I) collagen gene: exon location and coding potential for the prepropeptide.

Authors:  V E Tate; M H Finer; H Boedtker; P Doty
Journal:  Nucleic Acids Res       Date:  1983-01-11       Impact factor: 16.971

10.  Evidence for a structural mutation of procollagen type I in a patient with the Ehlers-Danlos syndrome type VII.

Authors:  B Steinmann; L Tuderman; L Peltonen; G R Martin; V A McKusick; D J Prockop
Journal:  J Biol Chem       Date:  1980-09-25       Impact factor: 5.157
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  12 in total

Review 1.  Molecular mechanisms of collagen gene expression.

Authors:  R Raghow; J P Thompson
Journal:  Mol Cell Biochem       Date:  1989-03-16       Impact factor: 3.396

2.  Homology between alpha 2(V) and alpha 1(III) collagen promoters and evidence for negatively acting elements in the alpha 2(V) first intron and 5' flanking sequences.

Authors:  D S Greenspan; S T Lee; B S Lee; G G Hoffman
Journal:  Gene Expr       Date:  1991-04

3.  The transcription of human alpha 1(I) procollagen gene (COL1A1) is suppressed by tumour necrosis factor-alpha through proximal short promoter elements: evidence for suppression mechanisms mediated by two nuclear-factorbinding sites.

Authors:  K Mori; A Hatamochi; H Ueki; A Olsen; S A Jimenez
Journal:  Biochem J       Date:  1996-11-01       Impact factor: 3.857

4.  A highly conserved, 5' untranslated, inverted repeat sequence is ineffective in translational control of the alpha 1(I) collagen gene.

Authors:  P Bornstein; J McKay; S Devarayalu; S C Cook
Journal:  Nucleic Acids Res       Date:  1988-10-25       Impact factor: 16.971

5.  Deletion analysis of the mouse alpha 1(III) collagen promoter.

Authors:  M Mudryj; B de Crombrugghe
Journal:  Nucleic Acids Res       Date:  1988-08-11       Impact factor: 16.971

6.  Structure of a full-length cDNA clone for the prepro alpha 2(I) chain of human type I procollagen. Comparison with the chicken gene confirms unusual patterns of gene conservation.

Authors:  H Kuivaniemi; G Tromp; M L Chu; D J Prockop
Journal:  Biochem J       Date:  1988-06-15       Impact factor: 3.857

7.  Formation of a type I collagen RNA dimer by intermolecular base-pairing of a conserved sequence around the translation initiation site.

Authors:  P Rossi; B de Crombrugghe
Journal:  Nucleic Acids Res       Date:  1987-11-11       Impact factor: 16.971

8.  Analysis of the COL1A1 and COL1A2 genes by PCR amplification and scanning by conformation-sensitive gel electrophoresis identifies only COL1A1 mutations in 15 patients with osteogenesis imperfecta type I: identification of common sequences of null-allele mutations.

Authors:  J Körkkö; L Ala-Kokko; A De Paepe; L Nuytinck; J Earley; D J Prockop
Journal:  Am J Hum Genet       Date:  1998-01       Impact factor: 11.025

9.  Regulation of the human alpha 2(1) procollagen gene by sequences adjacent to the CCAAT box.

Authors:  M Collins; V D Leaner; M Madikizela; M I Parker
Journal:  Biochem J       Date:  1997-02-15       Impact factor: 3.857

10.  A mutation in the pro alpha 2(I) gene (COL1A2) for type I procollagen in Ehlers-Danlos syndrome type VII: evidence suggesting that skipping of exon 6 in RNA splicing may be a common cause of the phenotype.

Authors:  N S Vasan; H Kuivaniemi; B E Vogel; R R Minor; J A Wootton; G Tromp; R Weksberg; D J Prockop
Journal:  Am J Hum Genet       Date:  1991-02       Impact factor: 11.025
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