Literature DB >> 6135195

Chick pro alpha 2 (I) collagen gene: exon location and coding potential for the prepropeptide.

V E Tate, M H Finer, H Boedtker, P Doty.   

Abstract

We report the DNA sequence of a cDNA clone complementary to the 5' end of the chick pro alpha 2(I) mRNA. The sequence enables us to deduce the amino acid sequence of this region, which has been refractory to conventional protein sequencing techniques. Its importance lies in the role of the prepropeptide in secretion, triple helix formation of the mature protein and initiation of fibrillogenesis. We have also located four of the five exons which code for this region on the genome. One exon is only 11bp in size and appears to code exclusively for the signal propeptidase cleavage site. This is an extreme example of an exon defining a functional unit.

Entities:  

Mesh：

Substances：

Year:  1983        PMID： 6135195      PMCID： PMC325692          DOI： 10.1093/nar/11.1.91

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  27 in total

1.  Isolation and translation of calvaria procollagen messenger ribonucleic acids.

Authors:  H Boedtker; A M Frischauf; H Lehrach
Journal:  Biochemistry       Date:  1976-11-02       Impact factor: 3.162

2.  Methylmercury as a reversible denaturing agent for agarose gel electrophoresis.

Authors:  J M Bailey; N Davidson
Journal:  Anal Biochem       Date:  1976-01       Impact factor: 3.365

3.  Correlation of procollagen mRNA levels in normal and transformed chick embryo fibroblasts with different rates of procollagen synthesis.

Authors:  D W Rowe; R C Moen; J M Davidson; P H Byers; P Bornstein; R D Palmiter
Journal:  Biochemistry       Date:  1978-05-02       Impact factor: 3.162

4.  Construction and characterization of pro alpha 1 collagen complementary deoxyribonucleic acid clones.

Authors:  H Lehrach; A M Frischauf; D Hanahan; J Wozney; F Fuller; H Boedtker
Journal:  Biochemistry       Date:  1979-07-10       Impact factor: 3.162

5.  Construction and characterization of a 2.5-kilobase procollagen clone.

Authors:  H Lehrach; A M Frischauf; D Hanahan; J Wozney; F Fuller; R Crkvenjakov; H Boedtker; P Doty
Journal:  Proc Natl Acad Sci U S A       Date:  1978-11       Impact factor: 11.205

6.  Characterization of the amino-terminal segment in procollagen palpha2 chain from dermatosparactic sheep.

Authors:  U Becker; O Helle; R Timpl
Journal:  FEBS Lett       Date:  1977-02-01       Impact factor: 4.124

7.  NH2-terminal sequence of the chick proalpha1(I) chain synthesized in the reticulocyte lysate system. Evidence for a transient hydrophobic leader sequence.

Authors:  R D Palmiter; J M Davidson; J Gagnon; D W Rowe; P Bornstein
Journal:  J Biol Chem       Date:  1979-03-10       Impact factor: 5.157

8.  Sequencing end-labeled DNA with base-specific chemical cleavages.

Authors:  A M Maxam; W Gilbert
Journal:  Methods Enzymol       Date:  1980       Impact factor: 1.600

9.  Collagen: molecular diversity in the body's protein scaffold.

Authors:  D R Eyre
Journal:  Science       Date:  1980-03-21       Impact factor: 47.728

10.  Amino acid sequence of the aminoterminal segment of dermatosparactic calf-skin procollagen type I.

Authors:  D Hörlein; P P Fietzek; E Wachter; C M Lapière; K Kühn
Journal:  Eur J Biochem       Date:  1979-08-15
View more
  18 in total

1.  Detection of point mutations in type I collagen by RNase digestion of RNA/RNA hybrids.

Authors:  D K Grange; G S Gottesman; M B Lewis; J C Marini
Journal:  Nucleic Acids Res       Date:  1990-07-25       Impact factor: 16.971

2.  Association of a change in chromatin structure with a tissue-specific switch in transcription start sites in the alpha 2(I) collagen gene.

Authors:  K M Beck; A H Seekamp; G R Askew; Z Mei; C M Farrell; S Wang; L N Lukens
Journal:  Nucleic Acids Res       Date:  1991-09-25       Impact factor: 16.971

3.  Selection of splice sites in pre-mRNAs with short internal exons.

Authors:  Z Dominski; R Kole
Journal:  Mol Cell Biol       Date:  1991-12       Impact factor: 4.272

4.  In vivo recognition of a vertebrate mini-exon as an exon-intron-exon unit.

Authors:  D A Sterner; S M Berget
Journal:  Mol Cell Biol       Date:  1993-05       Impact factor: 4.272

5.  Isolation and partial characterization of the entire human pro alpha 1(II) collagen gene.

Authors:  F O Sangiorgi; V Benson-Chanda; W J de Wet; M E Sobel; P Tsipouras; F Ramirez
Journal:  Nucleic Acids Res       Date:  1985-04-11       Impact factor: 16.971

6.  Large introns in the 3' end of the gene for the pro alpha 1 (IV) chain of human basement membrane collagen.

Authors:  R Soininen; L Tikka; L Chow; T Pihlajaniemi; M Kurkinen; D J Prockop; C D Boyd; K Tryggvason
Journal:  Proc Natl Acad Sci U S A       Date:  1986-03       Impact factor: 11.205

7.  Exon/intron organization of the chicken type II procollagen gene: intron size distribution suggests a minimal intron size.

Authors:  W B Upholt; L J Sandell
Journal:  Proc Natl Acad Sci U S A       Date:  1986-04       Impact factor: 11.205

8.  The 5' splice site: phylogenetic evolution and variable geometry of association with U1RNA.

Authors:  M Jacob; H Gallinaro
Journal:  Nucleic Acids Res       Date:  1989-03-25       Impact factor: 16.971

9.  Structure, evolution, and regulation of a fast skeletal muscle troponin I gene.

Authors:  A S Baldwin; E L Kittler; C P Emerson
Journal:  Proc Natl Acad Sci U S A       Date:  1985-12       Impact factor: 11.205

10.  Characterization of an intronless collagen gene family in the marine sponge Microciona prolifera.

Authors:  S Aho; H Turakainen; M L Onnela; H Boedtker
Journal:  Proc Natl Acad Sci U S A       Date:  1993-08-01       Impact factor: 11.205
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.