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Literature DB >> 4006370

Antipyrine clearance in pneumonia.

J Sonne, M Døssing, S Loft, P B Andreasen.

Abstract

Antipyrine clearance was estimated by a one-sample technique in 14 patients with acute fever and clinical pneumonia. Antipyrine clearance during the acute illness was 31.4 +/- 7.6 ml/min (X +/- SD). Fourteen and 28 days later during convalescence, clearance values were higher (47.8 +/- 18.9 and 49.2 +/- 15.0 ml/min, respectively). We conclude that microsomal hepatic drug metabolism in adults is impaired during pneumonia.

Entities: Disease Species

Mesh：

Substances：
Antipyrine

Year: 1985 PMID： 4006370 DOI： 10.1038/clpt.1985.117

Source DB: PubMed Journal: Clin Pharmacol Ther ISSN： 0009-9236 Impact factor: 6.875

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Cited

17 in total

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Authors: J F Westphal
Journal: Br J Clin Pharmacol Date: 2000-10 Impact factor: 4.335

Review 2. The pharmacological importance of cytochrome CYP3A4 in the palliation of symptoms: review and recommendations for avoiding adverse drug interactions.

Authors: Abdo Haddad; Mellar Davis; Ruth Lagman
Journal: Support Care Cancer Date: 2006-12-01 Impact factor: 3.603

3. Extrahepatic ischemia-reperfusion injury reduces hepatic oxidative drug metabolism as determined by serial antipyrine clearance.

Authors: B J Gurley; G W Barone; K Yamashita; S Polston; M Estes; A Harden
Journal: Pharm Res Date: 1997-01 Impact factor: 4.200

10. Steady-state pharmacokinetics and sputum penetration of lomefloxacin in patients with chronic obstructive pulmonary disease and acute respiratory tract infections.

Authors: J M Kovarik; A I Hoepelman; J M Smit; P A Sips; M Rozenberg-Arska; J H Glerum; J Verhoef
Journal: Antimicrob Agents Chemother Date: 1992-11 Impact factor: 5.191

Antipyrine clearance in pneumonia.

Review 1. Macrolide - induced clinically relevant drug interactions with cytochrome P-450A (CYP) 3A4: an update focused on clarithromycin, azithromycin and dirithromycin.

Review 2. The pharmacological importance of cytochrome CYP3A4 in the palliation of symptoms: review and recommendations for avoiding adverse drug interactions.

3. Extrahepatic ischemia-reperfusion injury reduces hepatic oxidative drug metabolism as determined by serial antipyrine clearance.

4. Lack of effect of zinc supplementation on antipyrine clearance in alcoholic liver disease.

5. Antipyrine and metronidazole metabolism during occupational exposure to gasoline.

Review 6. Drug disposition in pathophysiological conditions.

7. Decreased antipyrine clearance following endotoxin administration: in vivo evidence of the role of nitric oxide.

8. Influence of a very low calorie diet on the clearance of oxazepam and antipyrine in man.

9. Variability in drug metabolizing enzyme activity in HIV-infected patients.

10. Steady-state pharmacokinetics and sputum penetration of lomefloxacin in patients with chronic obstructive pulmonary disease and acute respiratory tract infections.