Continuous-flow hollow-fiber dialysis system for preparation of bovine carrier erythrocytes.

Small and large molecules were encapsulated in bovine RBC by a dialysis process. Encapsulation efficiencies were approximate 30%, yielding normal carrier cells. The new process of encapsulation used hollow fibers and was a continuous-flow system. Preparation of carrier RBC by hollow-fiber dialysis was compatible with blood banking principles. The continuous-flow system was easily assembled from commercially available hollow-fiber units.