Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Fragile X syndrome: a public health concern.

Literature DB >> 4003653

Fragile X syndrome: a public health concern.

Abstract

This study was designed to test for the fragile X syndrome [fra(X)] in institutionalized male patients with nonspecific mental retardation, referral patients, and relatives of fra(X) patients. Thirty-one of 91 (34.0 per cent) subjects tested were positive for the fra(X) chromosome; relatives had the largest percentage of positives. The data reflect the value of this test for detecting families having potential carriers who can benefit from genetic counseling.

Entities: Disease Species

Mesh：

Year: 1985 PMID： 4003653 PMCID： PMC1646299 DOI： 10.2105/ajph.75.7.771

Source DB: PubMed Journal: Am J Public Health ISSN： 0090-0036 Impact factor: 9.308

15 in total

1. Chromosome preparations of leukocytes cultured from human peripheral blood.

Authors: P S MOORHEAD; P C NOWELL; W J MELLMAN; D M BATTIPS; D A HUNGERFORD
Journal: Exp Cell Res Date: 1960-09 Impact factor: 3.905

2. A marker X chromosome.

Authors: H A Lubs
Journal: Am J Hum Genet Date: 1969-05 Impact factor: 11.025

3. X-linked mental retardation with macro-orchidism and the fragile site at Xq 27 or 28.

Authors: G R Sutherland; P L Ashforth
Journal: Hum Genet Date: 1979-04-17 Impact factor: 4.132

4. X-linked mental retardation: a study of 7 families.

Authors: P A Jacobs; T W Glover; M Mayer; P Fox; J W Gerrard; H G Dunn; D S Herbst
Journal: Am J Med Genet Date: 1980

5. "Fragile" X chromosome: major link to mental retardation.

Authors: G McBride
Journal: JAMA Date: 1981-10-09 Impact factor: 56.272

6. X-linked mental retardation, macro-orchidism, and the Xq27 fragile site.

Authors: G Turner; A Daniel; M Frost
Journal: J Pediatr Date: 1980-05 Impact factor: 4.406

7. Heritable fragile sites on human chromosomes. III. Detection of fra(X)(q27) in males with X-linked mental retardation and in their female relatives.

Authors: G R Sutherland
Journal: Hum Genet Date: 1979 Impact factor: 4.132

2. Clinical and cytogenetic survey of institutionalized mentally retarded patients with emphasis on the fragile-X syndrome.

Authors: M G Butler; D N Singh
Journal: J Intellect Disabil Res Date: 1993-04

2 in total

Fragile X syndrome: a public health concern.

1. Chromosome preparations of leukocytes cultured from human peripheral blood.

2. A marker X chromosome.

3. X-linked mental retardation with macro-orchidism and the fragile site at Xq 27 or 28.

4. X-linked mental retardation: a study of 7 families.

5. "Fragile" X chromosome: major link to mental retardation.

6. X-linked mental retardation, macro-orchidism, and the Xq27 fragile site.

7. Heritable fragile sites on human chromosomes. III. Detection of fra(X)(q27) in males with X-linked mental retardation and in their female relatives.

8. Distribution of spontaneous chromosome breaks in man.

9. Familial X-linked mental retardation with a marker X chromosome and its relationship to macro-orchidism.

10. X-linked mental retardation with macro-orchidism and marker-X chromosomes.

1. An important clinical approach in detecting the fragile X syndrome.

2. Clinical and cytogenetic survey of institutionalized mentally retarded patients with emphasis on the fragile-X syndrome.