Literature DB >> 4000394

gamma-Hydroxybutyrate uptake by rat brain striatal slices.

V Hechler, J J Bourguignon, C G Wermuth, P Mandel, M Maitre.   

Abstract

gamma-Hydroxybutyrate uptake by rat brain striatal slices was studied. The uptake was saturable with a Km of 702 +/- 107.10(-6) M. gamma-Hydroxybutyrate uptake was sodium dependent and inhibited by the omission of potassium. In addition, the effect of ouabain suggests that the transport is dependent on a cation gradient. Several analogues of gamma-hydroxybutyrate inhibit the transport system. GABA has no significant effect. This energy and cation dependent transport system is in favor of a transmitter or modulator role of gamma-hydroxybutyrate in the rat brain striatum.

Entities:  

Mesh：

Substances：

Year:  1985        PMID： 4000394     DOI： 10.1007/bf00964607

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  16 in total

1.  Growth and cultivation of dissociated neurons and glial cells from embryonic chick, rat and human brain in flask cultures.

Authors:  J Booher; M Sensenbrenner
Journal:  Neurobiology       Date:  1972

2.  Ligand: a versatile computerized approach for characterization of ligand-binding systems.

Authors:  P J Munson; D Rodbard
Journal:  Anal Biochem       Date:  1980-09-01       Impact factor: 3.365

3.  Positive cooperativity in high affinity binding sites for gamma-hydroxybutyric acid in rat brain.

Authors:  M Maitre; J F Rumigny; P Mandel
Journal:  Neurochem Res       Date:  1983-01       Impact factor: 3.996

4.  Depolarization-evoked release of gamma-hydroxybutyrate from rat brain slices.

Authors:  M Maitre; C Cash; D Weissmann-Nanopoulos; P Mandel
Journal:  J Neurochem       Date:  1983-07       Impact factor: 5.372

5.  Kinetics of in vivo conversion of gamma-[3H]aminobutyric acid to gamma-[3H]hydroxybutyric acid by rat brain.

Authors:  B I Gold; R H Roth
Journal:  J Neurochem       Date:  1977-05       Impact factor: 5.372

6.  Ontogeny of gamma-hydroxybutyric acid. I. Regional concentration in developing rat, monkey and human brain.

Authors:  O C Snead; B J Morley
Journal:  Brain Res       Date:  1981-07       Impact factor: 3.252

7.  Sodium dependence of GABA transport in rat hypothalamic synaptosomes.

Authors:  D D Wheeler
Journal:  J Neurosci Res       Date:  1980       Impact factor: 4.164

8.  High affinity binding sites for gamma-hydroxybutyric acid in rat brain.

Authors:  J Benavides; J F Rumigny; J J Bourguignon; C Cash; C G Wermuth; P Mandel; G Vincendon; M Maitre
Journal:  Life Sci       Date:  1982-03-15       Impact factor: 5.037

9.  Subcellular distribution of gamma-hydroxybutyrate binding sites in rat brain principal localization in the synaptosomal fraction.

Authors:  M Maitre; J F Rumigny; C Cash; P Mandel
Journal:  Biochem Biophys Res Commun       Date:  1983-01-14       Impact factor: 3.575

10.  Action of gamma-hydroxybutyrate and GABA on neurones of cultured rat central nervous system.

Authors:  L Hösli; E Hösli; R Lehmann; J Schneider; M Borner
Journal:  Neurosci Lett       Date:  1983-06-30       Impact factor: 3.046
View more
  4 in total

Review 1.  gamma-Hydroxybutyrate/sodium oxybate: neurobiology, and impact on sleep and wakefulness.

Authors:  Daniel Pardi; Jed Black
Journal:  CNS Drugs       Date:  2006       Impact factor: 5.749

2.  Gammahydroxybutyrate (GHB) receptor ligand effects on evoked synaptic field potentials in CA1 of the rat hippocampal slice.

Authors:  M A King; J S Thinschmidt; D W Walker
Journal:  J Neural Transm (Vienna)       Date:  1997       Impact factor: 3.575

3.  Effects of phospholipases, proteases and neuraminidase on gamma-hydroxybutyrate binding sites.

Authors:  V Hechler; M Mersel; H Dreyfus; M Maitre
Journal:  Mol Cell Biochem       Date:  1990-03-05       Impact factor: 3.396

4.  gamma-Hydroxybutyric acid binding sites: interaction with the GABA-benzodiazepine-picrotoxin receptor complex.

Authors:  O C Snead; A C Nichols; C C Liu
Journal:  Neurochem Res       Date:  1992-02       Impact factor: 3.996
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.