| Literature DB >> 1311434 |
O C Snead1, A C Nichols, C C Liu.
Abstract
The effect of three compounds known to allosterically modulate binding to the GABA/benzodiazepine/picrotoxin receptor complex on 4-hydroxy-2,3 [3H]butyric acid (GHB) binding was investigated. Pentobarbital, pentylenetetrazole, and picrotoxin enhanced [3H]GHB binding in a dose dependent fashion. Pentobarbital enhanced 4-hydroxy-2,3 [3H]butyric acid binding was associated with an increase in Bmax while pentylenetetrazole and picrotoxin altered the affinity of GHB for its binding site producing a decrease in Kd. These findings suggest that the GHB and GABA receptor complex may share certain moieties in common.Entities:
Mesh：
Substances：
Year: 1992 PMID： 1311434 DOI： 10.1007/bf00966800
Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996