Total knee replacement in patients with Parkinson's disease.

Total knee replacements were performed on three patients with Parkinson's disease. The rehabilitation of all three was, however, hampered by inhibition of the extensor mechanism, hamstring rigidity and poor muscular co-ordination. Medical treatment of the disease did not help. None of the patients became mobile, and all three gradually weakened and died. We suggest that, at least in some patients with Parkinson's disease, knee replacement is contra-indicated.