Literature DB >> 3997829

c-Ha-ras-1 proto-oncogene amplification and overexpression during the limited replicative life span of normal human fibroblasts.

A Srivastava, J S Norris, R J Shmookler Reis, S Goldstein.   

Abstract

The cellular proto-oncogene c-Ha-ras-1 undergoes up to 4-fold amplification during the limited replicative life span of normal human diploid fibroblasts in vitro. Levels of c-Ha-ras-1 messenger RNA and its p21 protein product are correspondingly elevated. Cellular proto-oncogene amplification and overexpression, although frequently associated with tumorigenesis, may thus occur during normal cellular growth.

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Year:  1985        PMID： 3997829

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  10 in total

1.  Sex-specific alterations in chromatin conformation of the brain of aging mouse.

Authors:  M K Thakur; A Asaithambi; S Mukherjee
Journal:  Mol Biol Rep       Date:  1999-12       Impact factor: 2.316

Review 2.  Relationship of eukaryotic DNA replication to committed gene expression: general theory for gene control.

Authors:  L P Villarreal
Journal:  Microbiol Rev       Date:  1991-09

3.  DNA amplification is rare in normal human cells.

Authors:  J A Wright; H S Smith; F M Watt; M C Hancock; D L Hudson; G R Stark
Journal:  Proc Natl Acad Sci U S A       Date:  1990-03       Impact factor: 11.205

4.  Identification of nuclear proteins that specifically interact with adeno-associated virus type 2 inverted terminal repeat hairpin DNA.

Authors:  H Ashktorab; A Srivastava
Journal:  J Virol       Date:  1989-07       Impact factor: 5.103

5.  Expression of cell cycle-dependent genes in young and senescent WI-38 fibroblasts.

Authors:  S R Rittling; K M Brooks; V J Cristofalo; R Baserga
Journal:  Proc Natl Acad Sci U S A       Date:  1986-05       Impact factor: 11.205

6.  Insulin-like growth factor binding protein 3 accumulates to high levels in culture medium of senescent and quiescent human fibroblasts.

Authors:  S Goldstein; E J Moerman; R A Jones; R C Baxter
Journal:  Proc Natl Acad Sci U S A       Date:  1991-11-01       Impact factor: 11.205

7.  Diverse gene sequences are overexpressed in werner syndrome fibroblasts undergoing premature replicative senescence.

Authors:  S Murano; R Thweatt; R J Shmookler Reis; R A Jones; E J Moerman; S Goldstein
Journal:  Mol Cell Biol       Date:  1991-08       Impact factor: 4.272

8.  Dysfunctional homologous recombination mediates genomic instability and progression in myeloma.

Authors:  Masood A Shammas; Robert J Shmookler Reis; Hemanta Koley; Ramesh B Batchu; Cheng Li; Nikhil C Munshi
Journal:  Blood       Date:  2008-12-02       Impact factor: 22.113

9.  Recombination and its roles in DNA repair, cellular immortalization and cancer.

Authors:  M A Shammas; R J Shmookler Reis
Journal:  Age (Omaha)       Date:  1999-04

10.  Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine.

Authors:  I Johansson; E Lundqvist; L Bertilsson; M L Dahl; F Sjöqvist; M Ingelman-Sundberg
Journal:  Proc Natl Acad Sci U S A       Date:  1993-12-15       Impact factor: 11.205
  10 in total

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