Literature DB >> 3458185

Expression of cell cycle-dependent genes in young and senescent WI-38 fibroblasts.

S R Rittling, K M Brooks, V J Cristofalo, R Baserga.   

Abstract

We studied the expression of 11 cell cycle-dependent genes in senescent WI-38 fibroblasts and compared the results to those obtained in WI-38 cells from early passages (young cells). Every gene we examined is expressed in the senescent cells at levels similar to those in the young cells, including two genes maximally expressed at the G1/S phase boundary--genes for thymidine kinase and histone H3. The results clearly show that senescent, noncycling WI-38 cells are not similar to quiescent cells. Rather, such senescent WI-38 cells may be blocked just prior to the onset of DNA synthesis.

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Year:  1986        PMID： 3458185      PMCID： PMC323504          DOI： 10.1073/pnas.83.10.3316

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  43 in total

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Journal:  Exp Cell Res       Date:  1973-02       Impact factor: 3.905

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Journal:  Exp Cell Res       Date:  1979-04       Impact factor: 3.905

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Authors:  P S Thomas
Journal:  Proc Natl Acad Sci U S A       Date:  1980-09       Impact factor: 11.205

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Journal:  J Cell Physiol       Date:  1977-03       Impact factor: 6.384

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Authors:  M Goyette; C J Petropoulos; P R Shank; N Fausto
Journal:  Science       Date:  1983-02-04       Impact factor: 47.728

8.  Approaches to mapping the temporal events in the cell cycle using conditional lethal mutants.

Authors:  A J Levine
Journal:  J Cell Physiol       Date:  1978-06       Impact factor: 6.384

9.  Comparative heterokaryon study of cellular senescence and the serum-deprived state.

Authors:  P S Rabinovitch; T H Norwood
Journal:  Exp Cell Res       Date:  1980-11       Impact factor: 3.905

10.  Functional organization of the Harvey murine sarcoma virus genome.

Authors:  E H Chang; J M Maryak; C M Wei; T Y Shih; R Shober; H L Cheung; R W Ellis; G L Hager; E M Scolnick; D R Lowy
Journal:  J Virol       Date:  1980-07       Impact factor: 5.103
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  42 in total

1.  Change of the death pathway in senescent human fibroblasts in response to DNA damage is caused by an inability to stabilize p53.

Authors:  A Seluanov; V Gorbunova; A Falcovitz; A Sigal; M Milyavsky; I Zurer; G Shohat; N Goldfinger; V Rotter
Journal:  Mol Cell Biol       Date:  2001-03       Impact factor: 4.272

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Authors:  A Satyanarayana; R A Greenberg; S Schaetzlein; J Buer; K Masutomi; W C Hahn; S Zimmermann; U Martens; M P Manns; K L Rudolph
Journal:  Mol Cell Biol       Date:  2004-06       Impact factor: 4.272

3.  Human diploid fibroblast cells in senescence; cycling through polyploidy to mitotic cells.

Authors:  Kirsten H Walen
Journal:  In Vitro Cell Dev Biol Anim       Date:  2006 Jul-Aug       Impact factor: 2.416

4.  Induction of senescence-like phenotypes by forced expression of hic-5, which encodes a novel LIM motif protein, in immortalized human fibroblasts.

Authors:  M Shibanuma; E Mochizuki; R Maniwa; J Mashimo; N Nishiya; S Imai; T Takano; M Oshimura; K Nose
Journal:  Mol Cell Biol       Date:  1997-03       Impact factor: 4.272

5.  Transcription factor AP-1 activity is required for initiation of DNA synthesis and is lost during cellular aging.

Authors:  K Riabowol; J Schiff; M Z Gilman
Journal:  Proc Natl Acad Sci U S A       Date:  1992-01-01       Impact factor: 11.205

Review 6.  Progeroid syndromes: probing the molecular basis of aging?

Authors:  D Kipling; R G Faragher
Journal:  Mol Pathol       Date:  1997-10

7.  The human homolog of the JE gene encodes a monocyte secretory protein.

Authors:  B J Rollins; P Stier; T Ernst; G G Wong
Journal:  Mol Cell Biol       Date:  1989-11       Impact factor: 4.272

8.  Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells.

Authors:  Q Chen; B N Ames
Journal:  Proc Natl Acad Sci U S A       Date:  1994-05-10       Impact factor: 11.205

9.  Extended life span of human endometrial stromal cells transfected with cloned origin-defective, temperature-sensitive simian virus 40.

Authors:  C A Rinehart; J S Haskill; J S Morris; T D Butler; D G Kaufman
Journal:  J Virol       Date:  1991-03       Impact factor: 5.103

10.  Adipocyte differentiation selectively represses the serum inducibility of c-jun and junB by reversible transcription-dependent mechanisms.

Authors:  H Wang; R E Scott
Journal:  Proc Natl Acad Sci U S A       Date:  1994-05-24       Impact factor: 11.205
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