Literature DB >> 3996406

Protein structure and gene organization of mouse lactate dehydrogenase-A isozyme.

S S Li, H F Tiano, K M Fukasawa, K Yagi, M Shimizu, F S Sharief, Y Nakashima, Y E Pan.   

Abstract

The complete covalent structure of the 331 amino acids of mouse lactate dehydrogenase (LDH) A4 isozyme has been determined by sequence analyses of both the protein and the genomic DNA. The mouse LDH-A gene spans a length of at least 7000 bases from the translation initiation codon ATG to the end of the 3' untranslated region, and it contains six introns that interrupt the protein-coding sequence. The relationships between the exon-intron organization of LDH-A gene and the structural-functional domains of the protein are discussed.

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Year:  1985        PMID： 3996406     DOI： 10.1111/j.1432-1033.1985.tb08914.x

Source DB:  PubMed          Journal:  Eur J Biochem        ISSN： 0014-2956


  20 in total

Review 1.  Interpreting cDNA sequences: some insights from studies on translation.

Authors:  M Kozak
Journal:  Mamm Genome       Date:  1996-08       Impact factor: 2.957

2.  Do exons code for structural or functional units in proteins?

Authors:  T W Traut
Journal:  Proc Natl Acad Sci U S A       Date:  1988-05       Impact factor: 11.205

3.  Molecular characterization of genetic mutations in human lactate dehydrogenase (LDH) B (H) variant.

Authors:  K Sudo; M Maekawa; A Tomonaga; T Tsukada; T Nakayama; M Kitamura; S S Li; T Kanno; J Toriumi
Journal:  Hum Genet       Date:  1992-05       Impact factor: 4.132

4.  Intron-dependent evolution of the nucleotide-binding domains within alcohol dehydrogenase and related enzymes.

Authors:  G Duester; H Jörnvall; G W Hatfield
Journal:  Nucleic Acids Res       Date:  1986-03-11       Impact factor: 16.971

5.  Molecular nature of spontaneous mutations in mouse lactate dehydrogenase-A processed pseudogenes.

Authors:  K M Fukasawa; M Tanimura; I Sakai; F S Sharief; F Z Chung; S S Li
Journal:  Genetics       Date:  1987-01       Impact factor: 4.562

Review 6.  An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs.

Authors:  M Kozak
Journal:  Nucleic Acids Res       Date:  1987-10-26       Impact factor: 16.971

7.  Complete nucleotide sequence of the mouse lactate dehydrogenase-A functional gene: comparison of the exon-intron organization of dehydrogenase genes.

Authors:  K M Fukasawa; S S Li
Journal:  Genetics       Date:  1987-05       Impact factor: 4.562

8.  Detection and characterization of new genetic mutations in individuals heterozygous for lactate dehydrogenase-B(H) deficiency using DNA conformation polymorphism analysis and silver staining.

Authors:  M Maekawa; K Sudo; M Kitajima; Y Matsuura; S S Li; T Kanno
Journal:  Hum Genet       Date:  1993-03       Impact factor: 4.132

9.  Duck lens epsilon-crystallin and lactate dehydrogenase B4 are identical: a single-copy gene product with two distinct functions.

Authors:  W Hendriks; J W Mulders; M A Bibby; C Slingsby; H Bloemendal; W W de Jong
Journal:  Proc Natl Acad Sci U S A       Date:  1988-10       Impact factor: 11.205

10.  Evolutionary relationships of lactate dehydrogenases (LDHs) from mammals, birds, an amphibian, fish, barley, and bacteria: LDH cDNA sequences from Xenopus, pig, and rat.

Authors:  S Tsuji; M A Qureshi; E W Hou; W M Fitch; S S Li
Journal:  Proc Natl Acad Sci U S A       Date:  1994-09-27       Impact factor: 11.205
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