| Literature DB >> 3989735 |
M T Tsuang, K D Bucher, J A Fleming, S V Faraone.
Abstract
The single major locus (SML) model of Bucher and Elston (1981) was applied to data collected in a long-term follow-up and family study of major effective disorders. Pedigree segregation analysis was used to test the hypothesis that bipolar and unipolar disorders are phenotypic variants of the same genotype at a SML. The particular SML model examined did not adequately describe the familial pattern of these disorders in families of bipolar and unipolar probands. Although other SML models may be superior, it is likely that the existence of a SML will be obscured by genetic heterogeneity.Entities:
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Year: 1985 PMID： 3989735 DOI： 10.1016/0022-3956(85)90065-2
Source DB: PubMed Journal: J Psychiatr Res ISSN： 0022-3956 Impact factor: 4.791