Literature DB >> 3988859

Determination of phthalic acid, mono-(2-ethylhexyl) phthalate and di-(2-ethylhexyl) phthalate in human plasma and in blood products.

H Shintani.   

Abstract

Pretreatment for the determination of phthalic acid, mono-(2-ethylhexyl) phthalate (MEHP) and di-(2-ethylhexyl) phthalate (DEHP) in human serum or plasma, and the determination of these compounds in blood products by high-performance liquid chromatography was studied. The amount of phthalic acid, MEHP and DEHP, migrated into blood products from a flexible bag, was studied. About 0.1% of DEHP in a flexible bag was found to have migrated into human platelet plasma. Most of the MEHP and phthalic acid detected in human platelet plasma was not derived from the flexible bag but was produced by enzymatic hydrolysis of the migrated DEHP. The amount of DEHP eluted into blood products from the flexible bag differed, depending upon storage time, storage temperature, etc.

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Year:  1985        PMID： 3988859     DOI： 10.1016/0378-4347(85)80041-4

Source DB:  PubMed          Journal:  J Chromatogr


  7 in total

1.  Testicular effects of di-n-butyl phthalate (DBP): biochemical and histopathological alterations.

Authors:  S P Srivastava; S Srivastava; D K Saxena; S V Chandra; P K Seth
Journal:  Arch Toxicol       Date:  1990       Impact factor: 5.153

2.  Testicular atrophy induced by di(2-ethylhexyl)phthalate: changes in histology, cell specific enzyme activities and zinc concentrations in rat testis.

Authors:  S Oishi
Journal:  Arch Toxicol       Date:  1986-12       Impact factor: 5.153

3.  Characterization of peroxisome proliferator-activated receptor alpha--independent effects of PPARalpha activators in the rodent liver: di-(2-ethylhexyl) phthalate also activates the constitutive-activated receptor.

Authors:  Hongzu Ren; Lauren M Aleksunes; Carmen Wood; Beena Vallanat; Michael H George; Curtis D Klaassen; J Christopher Corton
Journal:  Toxicol Sci       Date:  2009-10-22       Impact factor: 4.849

4.  Clinically relevant concentrations of di (2-ethylhexyl) phthalate (DEHP) uncouple cardiac syncytium.

Authors:  Nikki Gillum; Zaruhi Karabekian; Luther M Swift; Ronald P Brown; Matthew W Kay; Narine Sarvazyan
Journal:  Toxicol Appl Pharmacol       Date:  2009-01-22       Impact factor: 4.219

5.  Thyroid endocrine disruption in zebrafish larvae after exposure to mono-(2-ethylhexyl) phthalate (MEHP).

Authors:  Wenhui Zhai; Zhigang Huang; Li Chen; Cong Feng; Bei Li; Tanshi Li
Journal:  PLoS One       Date:  2014-03-21       Impact factor: 3.240

Review 6.  Toxicological characterization of phthalic Acid.

Authors:  Du Yeon Bang; In Kyung Lee; Byung-Mu Lee
Journal:  Toxicol Res       Date:  2011-12

7.  Unravelling the link between phthalate exposure and endometriosis in humans: a systematic review and meta-analysis of the literature.

Authors:  Alessandro Conforti; Luigi Carbone; Vittorio Simeon; Paolo Chiodini; Vincenzo Marrone; Francesca Bagnulo; Federica Cariati; Ida Strina; Carlo Alviggi
Journal:  J Assist Reprod Genet       Date:  2021-07-06       Impact factor: 3.412
  7 in total

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