| Literature DB >> 3988846 |
P De Pourcq, J Hoebus, E Roets, J Hoogmartens, H Vanderhaeghe.
Abstract
Amoxicillin, amoxicilloates, amoxicillin oligomers and amoxicillin piperazine-2,5-dione are separated by reversed-phase (C8) high-performance liquid chromatography with gradient elution. Quantitative results are reported for a number of samples. Amoxicillin trihydrate samples mostly contain amoxicilloate as the main impurity. Samples of the sodium salt also contain the piperazine-2,5-dione and the dimer. Higher oligomers such as the trimer and tetramer were not present in significant amounts. Several samples were also analysed by a mercurimetric titration method.Entities:
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Year: 1985 PMID： 3988846 DOI： 10.1016/s0021-9673(01)90462-5
Source DB: PubMed Journal: J Chromatogr