Literature DB >> 3987276

(-)-Gossypol: an active male antifertility agent.

S A Matlin, R Zhou, G Bialy, R P Blye, R H Naqvi, M C Lindberg.   

Abstract

The enantiomers of gossypol have been resolved by preparative HPLC of diastereomeric Schiff's base derivatives on a chiral bonded phase. Whereas (+)-gossypol has previously been reported to be inactive, (-)-gossypol is now shown to be active as a male oral antifertility agent in hamsters.

Entities:  

Keywords:  Animals, Laboratory; Clinical Research; Contraception; Contraception Research; Contraceptive Agents; Contraceptive Agents, Male; Family Planning; Male Contraception; Research And Development

Mesh：

Substances：

Year:  1985        PMID： 3987276     DOI： 10.1016/0010-7824(85)90027-7

Source DB:  PubMed          Journal:  Contraception        ISSN： 0010-7824            Impact factor:   3.375


  7 in total

Review 1.  An overview of the clinical pharmacology and therapeutic potential of gossypol as a male contraceptive agent and in gynaecological disease.

Authors:  D Wu
Journal:  Drugs       Date:  1989-09       Impact factor: 9.546

2.  Gene expression profiling during gland morphogenesis of a mutant and a glandless upland cotton.

Authors:  Quan Sun; Yingfan Cai; Yongfang Xie; Jianchuan Mo; Youlu Yuan; Yuzhen Shi; Shengwei Li; Huaizhong Jiang; Zheng Pan; Yunling Gao; Min Chen; Xiaohong He
Journal:  Mol Biol Rep       Date:  2009-11-04       Impact factor: 2.316

Review 3.  Prospects for pharmacological male contraception.

Authors:  S A Matlin
Journal:  Drugs       Date:  1994-12       Impact factor: 9.546

4.  Effect of racemic and (+)- and (-)-gossypol on the survival and development of Helicoverpa zea larvae.

Authors:  Robert D Stipanovic; Juan D Lopez; Michael K Dowd; Lorraine S Puckhaber; Sara E Duke
Journal:  J Chem Ecol       Date:  2006-05-19       Impact factor: 2.626

Review 5.  Atropisomerism in medicinal chemistry: challenges and opportunities.

Authors:  Sean T Toenjes; Jeffrey L Gustafson
Journal:  Future Med Chem       Date:  2018-01-30       Impact factor: 3.808

6.  Evidence for expression of 11β-hydroxysteroid dehydrogenase type3 (HSD11B3/HSD11B1L) in neonatal pig testis.

Authors:  Shuji Ohno; Satomi Nakagawara; Yoko Honda; Shizuo Nakajin
Journal:  Mol Cell Biochem       Date:  2013-06-04       Impact factor: 3.396

7.  Cytotoxicity of enantiomers of gossypol.

Authors:  A E Joseph; S A Matlin; P Knox
Journal:  Br J Cancer       Date:  1986-09       Impact factor: 7.640
  7 in total

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