Literature DB >> 2680434

An overview of the clinical pharmacology and therapeutic potential of gossypol as a male contraceptive agent and in gynaecological disease.

D Wu1.   

Abstract

Entities:  

Mesh：

Substances：

Year:  1989        PMID： 2680434     DOI： 10.2165/00003495-198938030-00001

Source DB:  PubMed          Journal:  Drugs        ISSN： 0012-6667            Impact factor:   9.546


× No keyword cloud information.
  35 in total

1.  [Interferonogenic activity of gossypol, a low-molecular substance].

Authors:  G S Khadzhibaev; V V Pogodina; R V Latypova; L M Vil'ner
Journal:  Antibiotiki       Date:  1978-04

2.  Comparative anti-fertility effects of gossypol enantiomers in male hamsters.

Authors:  M C Lindberg; R H Naqvi; S A Matlin; R H Zhou; G Bialy; R P Blye
Journal:  Int J Androl       Date:  1987-08

3.  Effects of gossypol on the kidney with special emphasis on potassium (K) excretion.

Authors:  C van Ypersele de Strihou; J P Dieu; E Marbaix
Journal:  Contraception       Date:  1988-02       Impact factor: 3.375

4.  [Gossypol treatment for menopausal functional bleeding, myoma of uterus and endometriosis--preliminary report (author's transl)].

Authors:  H L Han
Journal:  Zhongguo Yi Xue Ke Xue Yuan Xue Bao       Date:  1980-09

5.  Antispermatogenic action of gossypol in men.

Authors:  E M Coutinho; J F Melo; I Barbosa; S J Segal
Journal:  Fertil Steril       Date:  1984-09       Impact factor: 7.329

6.  High-performance liquid chromatography with electrochemical detection of gossypol in human plasma.

Authors:  M Z Wang; D F Wu; Y W Yu
Journal:  J Chromatogr       Date:  1985-10-11

7.  Clinical trial of gossypol as a male contraceptive drug. Part II. Hypokalemia study.

Authors:  G Z Liu; K C Lyle
Journal:  Fertil Steril       Date:  1987-09       Impact factor: 7.329

8.  Differential cytotoxic effect of gossypol on human melanoma, colon carcinoma, and other tissue culture cell lines.

Authors:  G P Tuszynski; G Cossu
Journal:  Cancer Res       Date:  1984-02       Impact factor: 12.701

9.  The toxicity of gossypol to the male rat.

Authors:  R Heywood; G K Lloyd; S K Majeed; C Gopinath
Journal:  Toxicology       Date:  1986-09       Impact factor: 4.221

10.  Gossypol inhibits Ehrlich ascites tumor cell proliferation.

Authors:  W W Tso
Journal:  Cancer Lett       Date:  1984-10       Impact factor: 8.679
View more
  19 in total

1.  AT-101 acts as anti-proliferative and hormone suppressive agent in mouse pituitary corticotroph tumor cells.

Authors:  B S Yurekli; B Karaca; A Kisim; E Bozkurt; H Atmaca; S Cetinkalp; G Ozgen; C Yilmaz; S Uzunoglu; R Uslu; F Saygili
Journal:  J Endocrinol Invest       Date:  2017-07-20       Impact factor: 4.256

2.  Synthesis of benzyl substituted naphthalenes from benzylidene tetralones.

Authors:  Lorraine M Deck; Quintino Mgani; Andrea Martinez; Alice Martinic; Lisa J Whalen; David L Vander Jagt; Robert E Royer
Journal:  Tetrahedron Lett       Date:  2012-01-25       Impact factor: 2.415

Review 3.  Bcl-2 antagonists: a proof of concept for CLL therapy.

Authors:  Kumudha Balakrishnan; Varsha Gandhi
Journal:  Invest New Drugs       Date:  2013-08-02       Impact factor: 3.850

4.  Involvement of Bcl-2, Src, and ERα in gossypol-mediated growth inhibition and apoptosis in human uterine leiomyoma and myometrial cells.

Authors:  Yan ZHU; Shu-wu XIE; Jian-feng ZHANG; Ting-ting ZHANG; Jie-yun ZHOU; Yang CAO; Lin CAO
Journal:  Acta Pharmacol Sin       Date:  2010-11-22       Impact factor: 6.150

5.  Gossypol, a BH3 mimetic, induces apoptosis in chronic lymphocytic leukemia cells.

Authors:  Kumudha Balakrishnan; William G Wierda; Michael J Keating; Varsha Gandhi
Journal:  Blood       Date:  2008-06-19       Impact factor: 22.113

6.  A preliminary clinical study of gossypol in advanced human cancer.

Authors:  R C Stein; A E Joseph; S A Matlin; D C Cunningham; H T Ford; R C Coombes
Journal:  Cancer Chemother Pharmacol       Date:  1992       Impact factor: 3.333

7.  The immunosuppressive effect of gossypol in mice is mediated by inhibition of lymphocyte proliferation and by induction of cell apoptosis.

Authors:  Wen-bin Xu; Li-hui Xu; Hong-song Lu; Dong-yun Ou-Yang; Huan-jing Shi; Jing-fang Di; Xian-hui He
Journal:  Acta Pharmacol Sin       Date:  2009-04-13       Impact factor: 6.150

8.  Molecular cloning and characterization of a novel lactate dehydrogenase gene from Clonorchis sinensis.

Authors:  Guang Yang; Chunxia Jing; Peixian Zhu; Xuchu Hu; Jin Xu; Zhongdao Wu; Xinbing Yu
Journal:  Parasitol Res       Date:  2006-02-15       Impact factor: 2.289

9.  Apogossypolone (ApoG2) induces ROS-dependent apoptosis and reduces invasiveness of PC12 cells in vitro and in vivo.

Authors:  Dengqiang Lin; Xiaoxia Li; Lieyu Xu; Jianpo Lian; Yunze Xu; Li Meng; Xin Xie; Xiaojing Wang; Hongchao He; Danfeng Xu; Chenghe Wang; Yu Zhu
Journal:  Am J Transl Res       Date:  2017-09-15       Impact factor: 4.060

Review 10.  Selected approaches for rational drug design and high throughput screening to identify anti-cancer molecules.

Authors:  Michael Hedvat; Luni Emdad; Swadesh K Das; Keetae Kim; Santanu Dasgupta; Shibu Thomas; Bin Hu; Shan Zhu; Rupesh Dash; Bridget A Quinn; Regina A Oyesanya; Timothy P Kegelman; Upneet K Sokhi; Siddik Sarkar; Eda Erdogan; Mitchell E Menezes; Praveen Bhoopathi; Xiang-Yang Wang; Martin G Pomper; Jun Wei; Bainan Wu; John L Stebbins; Paul W Diaz; John C Reed; Maurizio Pellecchia; Devanand Sarkar; Paul B Fisher
Journal:  Anticancer Agents Med Chem       Date:  2012-11       Impact factor: 2.505
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.