Literature DB >> 3987005

Two-dimensional proton nuclear magnetic resonance "maps" of acetaminophen metabolites in human urine.

J R Bales, J K Nicholson, P J Sadler.   

Abstract

Two-dimensional proton-proton correlated NMR spectra of concentrated urine from a subject who had ingested a 1-g dose of acetaminophen are reported. These "maps" provide a considerable simplification of the spectrum in comparison with conventional one-dimensional NMR spectra. In the present case, peaks for all the major acetaminophen metabolites, including the L-cysteinyl conjugate, can be unambiguously assigned.

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Year:  1985        PMID: 3987005

Source DB:  PubMed          Journal:  Clin Chem        ISSN: 0009-9147            Impact factor:   8.327


  12 in total

Review 1.  NMR studies of drug metabolism and disposition.

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Review 2.  Uses and limitations of nuclear magnetic resonance (NMR) spectroscopy in clinical pharmacokinetics.

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Journal:  Proteomics Clin Appl       Date:  2016-10-28       Impact factor: 3.494

4.  Isoform-specific therapeutic control of sulfonation in humans.

Authors:  Ian Cook; Ting Wang; Thomas S Leyh
Journal:  Biochem Pharmacol       Date:  2018-11-10       Impact factor: 5.858

5.  Proton NMR spectroscopic studies on the metabolism and biochemical effects of hydrazine in vivo.

Authors:  S M Sanins; J A Timbrell; C Elcombe; J K Nicholson
Journal:  Arch Toxicol       Date:  1992       Impact factor: 5.153

6.  Metabolic profiling and population screening of analgesic usage in nuclear magnetic resonance spectroscopy-based large-scale epidemiologic studies.

Authors:  Ruey Leng Loo; Muireann Coen; Timothy Ebbels; Olivier Cloarec; Elaine Maibaum; Magda Bictash; Ivan Yap; Paul Elliott; Jeremiah Stamler; Jeremy K Nicholson; Elaine Holmes
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7.  High-resolution proton nuclear magnetic resonance studies of urine from asphyxiated newborn infants.

Authors:  S Ma; L I Shieh; C C Huang
Journal:  Appl Biochem Biotechnol       Date:  1995-04       Impact factor: 2.926

8.  A comparison of self-reported analgesic use and detection of urinary ibuprofen and acetaminophen metabolites by means of metabonomics: the INTERMAP Study.

Authors:  Ruey Leng Loo; Queenie Chan; Ian J Brown; Claire E Robertson; Jeremiah Stamler; Jeremy K Nicholson; Elaine Holmes; Paul Elliott
Journal:  Am J Epidemiol       Date:  2012-01-05       Impact factor: 4.897

9.  The Pharmacometabodynamics of Gefitinib after Intravenous Administration to Mice: A Preliminary UPLC-IM-MS Study.

Authors:  Billy Molloy; Lauren Mullin; Adam King; Lee A Gethings; Robert S Plumb; Ian D Wilson
Journal:  Metabolites       Date:  2021-06-11

10.  (1)H NMR-based metabolic profiling of urinary tract infection: combining multiple statistical models and clinical data.

Authors:  Ekaterina Nevedomskaya; Tiziana Pacchiarotta; Artem Artemov; Axel Meissner; Cees van Nieuwkoop; Jaap T van Dissel; Oleg A Mayboroda; André M Deelder
Journal:  Metabolomics       Date:  2012-02-29       Impact factor: 4.290

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