| Literature DB >> 3979443 |
M L Murer-Orlando, A C Peterson.
Abstract
In situ nick translation of human and mouse chromosome preparations has provided further evidence that DNase I sensitivity correlates with transcriptionally active chromatin. Chromosomes from differentiating cells and particular chromosome regions, known to differ in transcriptional activity, generally reveal predicted differences in relative DNase I sensitivity. The application of a biotinylated nucleotide in these studies provides a new level of cytological resolution and offers the potential for further refinement.Entities:
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Year: 1985 PMID： 3979443 DOI： 10.1016/0014-4827(85)90117-x
Source DB: PubMed Journal: Exp Cell Res ISSN： 0014-4827 Impact factor: 3.905