Literature DB >> 3973960

Neurofibrillary tangles of Alzheimer's disease: an immunohistochemical study.

J P Brion, A M Couck, E Passareiro, J Flament-Durand.   

Abstract

The reactivity of neurofibrillary tangles (NFT) of Alzheimer's disease with several antisera has been studied by immunocytochemistry. They were heavily labelled by an antiserum prepared against isolated NFT; the latter also remained stainable by Bodian-silver method. Some NFT were labelled on vibratome sections by an antimicrotubular protein but remained able to be counterstained by Congo Red, suggesting this labelling could demonstrate material trapped in NFT. The immunoelectron labelling shows that the abnormal filaments, straight as well as 'twisted', are the only structures recognised by the anti-NFT serum. This labelling was prevented only by pre-incubation with fractions enriched in NFT, confirming the presence of unique antigenic determinants in the latter.

Entities:  

Mesh：

Year:  1985        PMID： 3973960

Source DB:  PubMed          Journal:  J Submicrosc Cytol        ISSN： 0022-4782


  60 in total

1.  Immune electron microscopic characterization of monoclonal antibodies to Alzheimer neurofibrillary tangles.

Authors:  M A Wrzolek; P A Merz; R Kascsak; I Grundke-Iqbal; K Iqbal; R Rubenstein; M Tonna-DeMasi; N L Goller; P Mehta; H M Wisniewski
Journal:  Am J Pathol       Date:  1992-08       Impact factor: 4.307

2.  Straight and paired helical filaments in Alzheimer disease have a common structural unit.

Authors:  R A Crowther
Journal:  Proc Natl Acad Sci U S A       Date:  1991-03-15       Impact factor: 11.205

3.  Alzheimer neurofibrillary tangles contain phosphorylated and hidden neurofilament epitopes.

Authors:  M C Haugh; A Probst; J Ulrich; J Kahn; B H Anderton
Journal:  J Neurol Neurosurg Psychiatry       Date:  1986-11       Impact factor: 10.154

4.  Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease.

Authors:  K S Kosik; C L Joachim; D J Selkoe
Journal:  Proc Natl Acad Sci U S A       Date:  1986-06       Impact factor: 11.205

5.  Reappraisal of neurofibrillary tangles. Immunohistochemical, ultrastructural, and immunoelectron microscopical studies.

Authors:  S Kato; H Nakamura; E Otomo
Journal:  Acta Neuropathol       Date:  1989       Impact factor: 17.088

6.  New aspects of the pathology of neurodegenerative disorders as revealed by ubiquitin antibodies.

Authors:  P N Leigh; A Probst; G E Dale; D P Power; J P Brion; A Dodson; B H Anderton
Journal:  Acta Neuropathol       Date:  1989       Impact factor: 17.088

7.  Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy.

Authors:  Tara L Spires; Jennifer D Orne; Karen SantaCruz; Rose Pitstick; George A Carlson; Karen H Ashe; Bradley T Hyman
Journal:  Am J Pathol       Date:  2006-05       Impact factor: 4.307

8.  Hydration water mobility is enhanced around tau amyloid fibers.

Authors:  Yann Fichou; Giorgio Schirò; François-Xavier Gallat; Cedric Laguri; Martine Moulin; Jérôme Combet; Michaela Zamponi; Michael Härtlein; Catherine Picart; Estelle Mossou; Hugues Lortat-Jacob; Jacques-Philippe Colletier; Douglas J Tobias; Martin Weik
Journal:  Proc Natl Acad Sci U S A       Date:  2015-04-27       Impact factor: 11.205

9.  The ubiquitin-proteasome system and the autophagic-lysosomal system in Alzheimer disease.

Authors:  Yasuo Ihara; Maho Morishima-Kawashima; Ralph Nixon
Journal:  Cold Spring Harb Perspect Med       Date:  2012-08-01       Impact factor: 6.915

10.  Multiple events lead to dendritic spine loss in triple transgenic Alzheimer's disease mice.

Authors:  Tobias Bittner; Martin Fuhrmann; Steffen Burgold; Simon M Ochs; Nadine Hoffmann; Gerda Mitteregger; Hans Kretzschmar; Frank M LaFerla; Jochen Herms
Journal:  PLoS One       Date:  2010-11-16       Impact factor: 3.240
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