Literature DB >> 3972101

Complete amino acid sequence of a new type of lethal neurotoxin from the venom of the funnel-web spider Atrax robustus.

D D Sheumack, R Claassens, N M Whiteley, M E Howden.   

Abstract

Robustoxin, the lethal neurotoxin isolated from the venom of the male Sydney funnel-web spider, Atrax robustus, is of unique structural type and physiological mode of action. The primary structure of this 42-residue peptide was determined to be H2N-Cys-Ala-Lys-Lys-Arg-Asn-Trp-Cys-Gly-Lys-Asn-Glu-Asp-Cys-Cys-Cys-Pro- Met-Lys-Cys-Ile-Tyr-Ala-Trp-Tyr-Asn-Gln-Gln-Gly-Ser-Cys-Gln-Thr-Thr-Ile- Thr-Gly-Leu-Phe-Lys-Lys-Cys-H. The disposition of disulphide-bridged cysteine residues at both the amino- and carboxy-termini and as a triplet at residues 14-16 appears to have no precedent amongst neurotoxins.

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Year:  1985        PMID： 3972101     DOI： 10.1016/0014-5793(85)81132-7

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  7 in total

1.  Neurotoxic acylpolyamines from spider venoms.

Authors:  K D McCormick; J Meinwald
Journal:  J Chem Ecol       Date:  1993-10       Impact factor: 2.626

2.  Synthesis, solution structure, and phylum selectivity of a spider delta-toxin that slows inactivation of specific voltage-gated sodium channel subtypes.

Authors:  Nahoko Yamaji; Michelle J Little; Hideki Nishio; Bert Billen; Elba Villegas; Yuji Nishiuchi; Jan Tytgat; Graham M Nicholson; Gerardo Corzo
Journal:  J Biol Chem       Date:  2009-07-10       Impact factor: 5.157

3.  Amino acid sequence of versutoxin, a lethal neurotoxin from the venom of the funnel-web spider Atrax versutus.

Authors:  M R Brown; D D Sheumack; M I Tyler; M E Howden
Journal:  Biochem J       Date:  1988-03-01       Impact factor: 3.857

4.  Modification of sodium channel gating and kinetics by versutoxin from the Australian funnel-web spider Hadronyche versuta.

Authors:  G M Nicholson; M Willow; M E Howden; T Narahashi
Journal:  Pflugers Arch       Date:  1994-10       Impact factor: 3.657

5.  Immunization with a synthetic robustoxin derivative lacking disulphide bridges protects against a potentially lethal challenge with funnel-web spider (Atrax robustus) venom.

Authors:  Alfio Comis; Margaret Tyler; Ewan Mylecharane; Ian Spence; Merlin Howden
Journal:  J Biosci       Date:  2009-03       Impact factor: 1.826

6.  The Cystine Knot Is Responsible for the Exceptional Stability of the Insecticidal Spider Toxin ω-Hexatoxin-Hv1a.

Authors:  Volker Herzig; Glenn F King
Journal:  Toxins (Basel)       Date:  2015-10-26       Impact factor: 4.546

Review 7.  Venomous and poisonous Australian animals of veterinary importance: a rich source of novel therapeutics.

Authors:  Margaret C Hardy; Jonathon Cochrane; Rachel E Allavena
Journal:  Biomed Res Int       Date:  2014-07-21       Impact factor: 3.411
  7 in total

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