Literature DB >> 3355530

Amino acid sequence of versutoxin, a lethal neurotoxin from the venom of the funnel-web spider Atrax versutus.

M R Brown1, D D Sheumack, M I Tyler, M E Howden.   

Abstract

The complete amino acid sequence of versutoxin, a lethal neurotoxic polypeptide isolated from the venom of male and female funnel-web spiders of the species Atrax versutus, was determined. Sequencing was performed in a gas-phase protein sequencer by automated Edman degradation of the S-carboxymethylated toxin and fragments of it produced by reaction with CNBr. Versutoxin consisted of a single chain of 42 amino acid residues. It was found to have a high proportion of basic residues and of cystine. The primary structure showed marked homology with that of robustoxin, a novel neurotoxin recently isolated from the venom of another funnel-web-spider species, Atrax robustus.

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Year:  1988        PMID： 3355530      PMCID： PMC1148870          DOI： 10.1042/bj2500401

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  10 in total

1.  Prediction of sequential antigenic regions in proteins.

Authors:  G W Welling; W J Weijer; R van der Zee; S Welling-Wester
Journal:  FEBS Lett       Date:  1985-09-02       Impact factor: 4.124

2.  New hydrophilicity scale derived from high-performance liquid chromatography peptide retention data: correlation of predicted surface residues with antigenicity and X-ray-derived accessible sites.

Authors:  J M Parker; D Guo; R S Hodges
Journal:  Biochemistry       Date:  1986-09-23       Impact factor: 3.162

Review 3.  Protein surface analysis. Methods for identifying antigenic determinants and other interaction sites.

Authors:  T P Hopp
Journal:  J Immunol Methods       Date:  1986-04-03       Impact factor: 2.303

4.  Multiple peptide composition of the large and small subunits of Nicotiana tabacum fraction I protein ascertained by fingerprinting and electrofocusing.

Authors:  S D Kung; K Sakano; S G Wildman
Journal:  Biochim Biophys Acta       Date:  1974-09-13

5.  Complete amino acid sequence of a new type of lethal neurotoxin from the venom of the funnel-web spider Atrax robustus.

Authors:  D D Sheumack; R Claassens; N M Whiteley; M E Howden
Journal:  FEBS Lett       Date:  1985-02-11       Impact factor: 4.124

6.  A gas-liquid solid phase peptide and protein sequenator.

Authors:  R M Hewick; M W Hunkapiller; L E Hood; W J Dreyer
Journal:  J Biol Chem       Date:  1981-08-10       Impact factor: 5.157

7.  Complete amino acid analysis of proteins from a single hydrolysate.

Authors:  R J Simpson; M R Neuberger; T Y Liu
Journal:  J Biol Chem       Date:  1976-04-10       Impact factor: 5.157

8.  A comparative study of properties and toxic constituents of funnel web spider (Atrax) venoms.

Authors:  D D Sheumack; B A Baldo; P R Carroll; F Hampson; M E Howden; A Skorulis
Journal:  Comp Biochem Physiol C       Date:  1984

9.  Antivenom to the venom of the male Sydney funnel-web spider Atrax robustus: preliminary report.

Authors:  S K Sutherland
Journal:  Med J Aust       Date:  1980-10-18       Impact factor: 7.738

10.  Human liver alcohol dehydrogenase. 1. The primary structure of the beta 1 beta 1 isoenzyme.

Authors:  J Hempel; R Bühler; R Kaiser; B Holmquist; C de Zalenski; J P von Wartburg; B Vallee; H Jörnvall
Journal:  Eur J Biochem       Date:  1984-12-17
  10 in total
  4 in total

1.  Neurotoxic acylpolyamines from spider venoms.

Authors:  K D McCormick; J Meinwald
Journal:  J Chem Ecol       Date:  1993-10       Impact factor: 2.626

2.  Biochemical analysis of tarantula venom (Eurypelma californicum).

Authors:  A Savel-Niemann; D Roth
Journal:  Naturwissenschaften       Date:  1989-05

3.  Modification of sodium channel gating and kinetics by versutoxin from the Australian funnel-web spider Hadronyche versuta.

Authors:  G M Nicholson; M Willow; M E Howden; T Narahashi
Journal:  Pflugers Arch       Date:  1994-10       Impact factor: 3.657

4.  Immunization with a synthetic robustoxin derivative lacking disulphide bridges protects against a potentially lethal challenge with funnel-web spider (Atrax robustus) venom.

Authors:  Alfio Comis; Margaret Tyler; Ewan Mylecharane; Ian Spence; Merlin Howden
Journal:  J Biosci       Date:  2009-03       Impact factor: 1.826
  4 in total

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