Literature DB >> 3972088

Different biological behavior of AKR lymphoma cells from primary and metastatic tumors.

J Leibovici, Y Stark, S Kopel.   

Abstract

AKR lymphoma cells derived from primary s.c. tumors (PT) and cells from their metastases (MT) were inoculated into recipient mice in order to compare their malignant behavior. A higher malignant potential of MT compared to PT cells was found. The results support the hypothesis that metastasis is a process of selection of cells possessing a potential to metastasize, which preexist in the primary tumor. In the model used, both the selection of 'variants' of malignancy and the assay of malignancy were as close as possible to natural tumor progression.

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Year:  1985        PMID： 3972088     DOI： 10.1007/bf02004530

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  22 in total

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Journal:  J Natl Cancer Inst       Date:  1961-07       Impact factor: 13.506

2.  Effects of high-molecular levan on the growth and spread of lymphoma in AKR mice.

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Journal:  Cancer Res       Date:  1975-08       Impact factor: 12.701

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Journal:  J Natl Cancer Inst       Date:  1966-04       Impact factor: 13.506

4.  Adriamycin effect on the Lewis lung carcinoma. Comparison between the original line and its derivative subline.

Authors:  C Greco; F Calbresi; M Caputo; A Corsi; A Sacchi; G Zupi
Journal:  Eur J Cancer       Date:  1980-09       Impact factor: 9.162

5.  Induction of a tumor with greatly increased metastatic growth potential by injection of cells from a low-metastatic H-2 heterozygous tumor cell line into an H-2 incompatible parental strain.

Authors:  R S Kerbel; R R Twiddy; D M Robertson
Journal:  Int J Cancer       Date:  1978-11-15       Impact factor: 7.396

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Authors:  J W Dennis; R S Kerbel
Journal:  Cancer Res       Date:  1981-01       Impact factor: 12.701

7.  Metastasis: differences between cancer cells in primary and secondary tumors.

Authors:  L Weiss
Journal:  Pathobiol Annu       Date:  1980

8.  Cancer metastasis is selective or random depending on the parent tumour population.

Authors:  J E Talmadge; I J Fidler
Journal:  Nature       Date:  1982-06-17       Impact factor: 49.962

9.  [Short-term incubation in vitro with precursors of nucleic acids on human primary tumors and metastases of carcinoma of the breast (author's transl)].

Authors:  M Kaufmann; F Kubli; M Volm; D von Fournier; W Reus
Journal:  Strahlentherapie       Date:  1978-04

10.  Do metastases arise from pre-existing subpopulations of cancer cells?

Authors:  L Weiss; J C Holmes; P M Ward
Journal:  Br J Cancer       Date:  1983-01       Impact factor: 7.640
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  2 in total

1.  Effect of hyperthermia and thermochemotherapy on primary and metastatic tumour cells of AKR lymphoma.

Authors:  G Klorin; A Siegal; B Bar-Shira-Maymon; O Klein; J Leibovici
Journal:  Int J Exp Pathol       Date:  1990-08       Impact factor: 1.925

2.  Differential sensitivity to hyperthermia of the F1 and F10 B16 melanoma variants.

Authors:  J Leibovici; G Klorin; M Huszar; S Hoenig; M Michowitz
Journal:  Int J Exp Pathol       Date:  1991-04       Impact factor: 1.925
  2 in total

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