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Literature DB >> 3967736

Changes in the cardiac glutathione status after ischemia and reperfusion.

S Curello, C Ceconi, C Bigoli, R Ferrari, A Albertini, C Guarnieri.

Abstract

In the isolated and perfused rabbit heart ischemia induced a rapid decline of contractility, associated with a reduction of the content of tissue GSH with no significant changes in GSSG. Reperfusion induced a small recovery of contractility, a substantial release of total glutathione and a further decrease in the content of tissue GSH with a significant increase of tissue GSSG. Glutathione reductase and glutathione peroxidase activities were not affected by ischemia and reperfusion. This study suggests a possible role for glutathione in the determination of functional damage induced by myocardial ischemia and reperfusion.

Entities: Chemical Disease Species

Mesh：

Substances：
Glutathione

Year: 1985 PMID： 3967736 DOI： 10.1007/bf02005863

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

15 in total

1. Oxidation in the NADP system and release of GSSG from hemoglobin-free perfused rat liver during peroxidatic oxidation of glutathione by hydroperoxides.

Authors: H Sies; C Gerstenecker; H Menzel; L Flohé
Journal: FEBS Lett Date: 1972-10-15 Impact factor: 4.124

Changes in the cardiac glutathione status after ischemia and reperfusion.

1. Oxidation in the NADP system and release of GSSG from hemoglobin-free perfused rat liver during peroxidatic oxidation of glutathione by hydroperoxides.

2. Measurement of oxidized glutathione and total glutathione in the perfused rat heart.

3. A role for glutathione in muscle contraction.

4. The effects of ruthenium red on mitochondrial function during post-ischaemic reperfusion.

5. A correlation between glutathione levels and cellular damage in isolated hepatocytes.

6. Prolonged protective effect of propranolol on hypoxic heart muscle.

7. Role of oxygen in the cellular damage induced by re-oxygenation of hypoxic heart.

8. Glutathione peroxidase activity and release of glutathione from oxygen-deficient perfused rat heart.

9. The effect of doxorubicin on hepatic and cardiac glutathione.

10. Inhibition of ATP-dependent microsomal Ca2+ sequestration during oxidative stress and its prevention by glutathione.

1. Inducible collagenolytic activity in isolated perfused rat hearts.

2. The effects of a high dose of ascorbate on ischemia-reperfusion-induced mitochondrial dysfunction in canine hearts.

3. Lipid peroxidation during myocardial reperfusion.

4. Oxidation and reduction of pig skeletal muscle ryanodine receptors.

5. Myocardial matrix metalloproteinase(s): localization and activation.

6. Biosynthesis and degradation of nodule-specific Rhizobium loti compounds in Lotus nodules.

7. Glutathione alters calcium responsiveness of cardiac skinned fibers.

8. Effect of pyruvate on rat heart thiol status during ischemia and hypoxia followed by reperfusion.

9. Protective effect of N-acetylcysteine on ischaemia-induced myocardial damage in canine heart.

Review 10. The occurrence of oxidative stress during reperfusion in experimental animals and men.