Predominant localization of dihydroxyacetone-phosphate acyltransferase activity in renal peroxisomes of male and female mice.

The subcellular localization of DHAPAT activity in male and female albino mouse kidneys was investigated by density gradient centrifugation. DHAPAT has a predominantly peroxisomal distribution in both male and female kidneys; however some activity is also distributed in a less dense region of the gradient, predominantly containing microsomes. Peroxisomal fractions also contain some lactate dehydrogenase activity and approximately 9% of the cellular NAD-dependent alpha-glycerophosphate dehydrogenase activity.