Literature DB >> 2822005

Peroxisomal localization of glucose-6-phosphate dehydrogenase and pyrophosphate-stimulated dihydroxyacetone-phosphate acyltransferase in mouse kidney.

B N Patel1, M I Mackness, M J Connock.   

Abstract

1. The subcellular localization of dihydroxyacetone-phosphate acyltransferase (DHAPAT) (assayed in the presence of pyrophosphate) and glucose-6-phosphate dehydrogenase (NADP+-dependent) activity in mouse kidney was investigated by density-gradient centrifugation. 2. DHAPAT has a predominantly peroxisomal distribution, and the activity in purified peroxisomes is stimulated by various organic and inorganic phosphate-containing compounds. The pH optimum is acid. 3. Approx. 10% of the cellular NADP+-dependent glucose-6-phosphate dehydrogenase activity is associated with peroxisomal fractions and may provide a source of NADPH for the peroxisomal reduction of acyl-dihydroxyacetone phosphate formed by DHAPAT activity.

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Year:  1987        PMID： 2822005      PMCID： PMC1148010          DOI： 10.1042/bj2440443

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  18 in total

1.  The subcellular distribution of acyl CoA: dihydroxyacetone phosphate acyl transferase in guinea pig liver.

Authors:  C L Jones; A K Hajra
Journal:  Biochem Biophys Res Commun       Date:  1977-06-20       Impact factor: 3.575

2.  Reduced levels of peroxisomal enzymes in the kidney of the genetically obese (ob/ob) mouse. Contrast with liver.

Authors:  A Silcox; K Burdett; M J Connock
Journal:  Biochem Int       Date:  1983-09

3.  Glycerolipid synthetic capacity of rat liver peroxisomes.

Authors:  L M Ballas; P B Lazarow; R M Bell
Journal:  Biochim Biophys Acta       Date:  1984-09-12

4.  Deficiency of acyl-CoA: dihydroxyacetone phosphate acyltransferase in patients with Zellweger (cerebro-hepato-renal) syndrome.

Authors:  R B Schutgens; G J Romeyn; R J Wanders; H van den Bosch; G Schrakamp; H S Heymans
Journal:  Biochem Biophys Res Commun       Date:  1984-04-16       Impact factor: 3.575

5.  Glucose-6-phosphate dehydrogenase of rat liver peroxisomes.

Authors:  L F Panchenko; V D Antonenkov
Journal:  Experientia       Date:  1984-05-15

6.  Severe plasmalogen deficiency in tissues of infants without peroxisomes (Zellweger syndrome).

Authors:  H S Heymans; R B Schutgens; R Tan; H van den Bosch; P Borst
Journal:  Nature       Date:  1983 Nov 3-9       Impact factor: 49.962

7.  Deficiency of enzymes catalyzing the biosynthesis of glycerol-ether lipids in Zellweger syndrome. A new category of metabolic disease involving the absence of peroxisomes.

Authors:  N S Datta; G N Wilson; A K Hajra
Journal:  N Engl J Med       Date:  1984-10-25       Impact factor: 91.245

8.  Rat liver dihydroxyacetone-phosphate acyltransferases and their contribution to glycerolipid synthesis.

Authors:  P E Declercq; H P Haagsman; P Van Veldhoven; L J Debeer; L M Van Golde; G P Mannaerts
Journal:  J Biol Chem       Date:  1984-07-25       Impact factor: 5.157

9.  Predominant localization of dihydroxyacetone-phosphate acyltransferase activity in renal peroxisomes of male and female mice.

Authors:  M I Mackness; M J Connock
Journal:  Comp Biochem Physiol B       Date:  1985

10.  A study of the glycerol phosphate acyltransferase and dihydroxyacetone phosphate acyltransferase activities in rat liver mitochondrial and microsomal fractions. Relative distribution in parenchymal and non-parenchymal cells, effects of N-ethylmaleimide, palmitoyl-coenzyme A concentration, starvation, adrenalectomy and anti-insulin serum treatment.

Authors:  E J Bates; E D Saggerson
Journal:  Biochem J       Date:  1979-09-15       Impact factor: 3.857
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  5 in total

1.  A dehydrogenase-mediated recycling system of NADPH in plant peroxisomes.

Authors:  F J Corpas; J B Barroso; L M Sandalio; S Distefano; J M Palma; J A Lupiáñez; L A Del Río
Journal:  Biochem J       Date:  1998-03-01       Impact factor: 3.857

2.  D-aspartate oxidase in rat, bovine and sheep kidney cortex is localized in peroxisomes.

Authors:  K Zaar; A Völkl; H D Fahimi
Journal:  Biochem J       Date:  1989-07-01       Impact factor: 3.857

3.  Purification of guinea pig small intestinal peroxisomes and the subcellular localization of glucose-6-phosphate dehydrogenase.

Authors:  P S Tappia; C J Jones; M J Connock
Journal:  Mol Cell Biochem       Date:  1998-02       Impact factor: 3.396

4.  Studies of dihydroxyacetone phosphate acyltransferase in rat small intestine. Subcellular localization and effect of partially hydrogenated fish oil and clofibrate.

Authors:  B Ruyter; J S Lund; M S Thomassen; E N Christiansen
Journal:  Biochem J       Date:  1992-03-01       Impact factor: 3.857

5.  Knockdown of both mitochondrial isocitrate dehydrogenase enzymes in pancreatic beta cells inhibits insulin secretion.

Authors:  Michael J MacDonald; Laura J Brown; Melissa J Longacre; Scott W Stoker; Mindy A Kendrick; Noaman M Hasan
Journal:  Biochim Biophys Acta       Date:  2013-07-20
  5 in total

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