Literature DB >> 3959034

Absolute configuration of (-)-5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-alpha]pyrrole-1-carboxylic acid, the active enantiomer of ketorolac.

A Guzmán, F Yuste, R A Toscano, J M Young, A R Van Horn, J M Muchowski.   

Abstract

The (-)-S isomer of 5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-alpha]pyrrole-1-carboxylic acid is about 60 times more potent than the (+)-R isomer in the carrageenan edema test and ca. 230 times more active than the (+)-R isomer in the mouse phenylquinone writhing assay.

Entities:  

Mesh:

Substances:

Year:  1986        PMID: 3959034     DOI: 10.1021/jm00154a027

Source DB:  PubMed          Journal:  J Med Chem        ISSN: 0022-2623            Impact factor:   7.446


  12 in total

Review 1.  Enantioselective pharmacodynamics and pharmacokinetics of chiral non-steroidal anti-inflammatory drugs.

Authors:  A M Evans
Journal:  Eur J Clin Pharmacol       Date:  1992       Impact factor: 2.953

Review 2.  Chirality and nonsteroidal anti-inflammatory drugs.

Authors:  P J Hayball
Journal:  Drugs       Date:  1996       Impact factor: 9.546

Review 3.  Preclinical and clinical development of dexketoprofen.

Authors:  D Mauleón; R Artigas; M L García; G Carganico
Journal:  Drugs       Date:  1996       Impact factor: 9.546

4.  Intravenous prediction of human pharmacokinetic parameters for ketorolac, a non-steroidal anti-inflammatory agent, using allometry approach.

Authors:  Ravindranath Reddy Gilibili; Ramesh Mullangi; Nuggehally R Srinivas
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2011-03-05       Impact factor: 2.441

5.  Enantiomer-specific ketorolac pharmacokinetics in young women, including pregnancy and postpartum period.

Authors:  Aida Kulo; Anne Smits; Sanita Maleškić; Marc Van de Velde; Kristel Van Calsteren; Jan De Hoon; Rene Verbesselt; Jan Deprest; Karel Allegaert
Journal:  Bosn J Basic Med Sci       Date:  2017-02-21       Impact factor: 3.363

Review 6.  Clinical pharmacokinetics of ketorolac tromethamine.

Authors:  D R Brocks; F Jamali
Journal:  Clin Pharmacokinet       Date:  1992-12       Impact factor: 6.447

Review 7.  Topical ocular delivery of NSAIDs.

Authors:  Munish Ahuja; Avinash S Dhake; Surendra K Sharma; Dipak K Majumdar
Journal:  AAPS J       Date:  2008-04-25       Impact factor: 4.009

8.  The pharmacokinetics of ketorolac enantiomers following intramuscular administration of the racemate.

Authors:  P J Hayball; J Wrobel; J G Tamblyn; R L Nation
Journal:  Br J Clin Pharmacol       Date:  1994-01       Impact factor: 4.335

9.  Scope and mechanism of direct indole and pyrrole couplings adjacent to carbonyl compounds: total synthesis of acremoauxin A and oxazinin 3.

Authors:  Jeremy M Richter; Brandon W Whitefield; Thomas J Maimone; David W Lin; M Pilar Castroviejo; Phil S Baran
Journal:  J Am Chem Soc       Date:  2007-09-27       Impact factor: 15.419

10.  New chiral reverse phase HPLC method for enantioselective analysis of ketorolac using chiral AGP column.

Authors:  Sunil K Dubey; Jangala Hemanth; Chiranjeevi Venkatesh K; R N Saha; S Pasha
Journal:  J Pharm Anal       Date:  2012-07-22
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.