Literature DB >> 3958900

Dissolution and partition thermodynamic functions of some nonsteroidal anti-inflammatory drugs.

A Fini, M Laus, I Orienti, V Zecchi.   

Abstract

Solubility values of a selected group of nonsteroidal anti-inflammatory drugs have been determined in water and 1-octanol as a function of temperature. Thermodynamic functions of dissolution and partition have been calculated and discussed with respect to various physical parameters of each solute and the two solvents. The calculated solubility values show good agreement with the experimental values. The analysis of the experimental solubility values of these compounds in terms of solid-state contribution and solute-solvent interaction suggests the different importance of these parameters in promoting solubility of solid nonelectrolytes.

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Year:  1986        PMID： 3958900     DOI： 10.1002/jps.2600750106

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN： 0022-3549            Impact factor:   3.534


  8 in total

1.  Gastrointestinal ulcerations induced by anti-inflammatory drugs in rats. Physicochemical and biochemical factors involved.

Authors:  W S Beck; H T Schneider; K Dietzel; B Nuernberg; K Brune
Journal:  Arch Toxicol       Date:  1990       Impact factor: 5.153

2.  Effects of soil moisture depletion on vegetable crop uptake of pharmaceuticals and personal care products (PPCPs).

Authors:  Sergio Santiago; Deborah M Roll; Chittaranjan Ray; Clinton Williams; Philip Moravcik; Allan Knopf
Journal:  Environ Sci Pollut Res Int       Date:  2016-07-22       Impact factor: 4.223

3.  Fullerene C60 containing porphyrin-like metal center as drug delivery system for ibuprofen drug.

Authors:  Elham Alipour; Farzaneh Alimohammady; Alexei Yumashev; Andino Maseleno
Journal:  J Mol Model       Date:  2019-12-13       Impact factor: 1.810

4.  Comparison of Skin Permeation and Putative Anti-Inflammatory Activity of Commercially Available Topical Products Containing Ibuprofen and Diclofenac.

Authors:  Julie Pradal
Journal:  J Pain Res       Date:  2020-11-04       Impact factor: 3.133

5.  Development and evaluation of pharmacosomes of aceclofenac.

Authors:  A Semalty; Mona Semalty; B S Rawat; D Singh; M S M Rawat
Journal:  Indian J Pharm Sci       Date:  2010-09       Impact factor: 0.975

6.  Hydration of the Carboxylate Group in Anti-Inflammatory Drugs: ATR-IR and Computational Studies of Aqueous Solution of Sodium Diclofenac.

Authors:  Elena O Levina; Nikita V Penkov; Natalia N Rodionova; Sergey A Tarasov; Daria V Barykina; Mikhail V Vener
Journal:  ACS Omega       Date:  2018-01-10

7.  A fugacity model assessment of ibuprofen, diclofenac, carbamazepine, and their transformation product concentrations in an aquatic environment.

Authors:  Tuomas M A Nurmi; Toni K Kiljunen; Juha S Knuutinen
Journal:  Environ Sci Pollut Res Int       Date:  2018-11-05       Impact factor: 4.223

8.  Prediction of aqueous intrinsic solubility of druglike molecules using Random Forest regression trained with Wiki-pS0 database.

Authors:  Alex Avdeef
Journal:  ADMET DMPK       Date:  2020-03-04
  8 in total

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