Literature DB >> 3957859

Kinetics of 3H-serotonin uptake by platelets in infantile autism and developmental language disorder (including five pairs of twins).

T Katsui, M Okuda, S Usuda, T Koizumi.   

Abstract

The kinetics of 5-HT uptake by platelets was studied in cases of infantile autism and developmental language disorder (DLD) and normal subjects. Two patients of the autism group were twins, and the seven patients of the DLD group were members of four pairs of twins. The Vmax values (means +/- SD) for autism and DLD were 6.46 +/- .90 pmol 5-HT/10(7) cells/min and 4.85 +/- 1.50 pmol 5-HT/10(7) cells/min, respectively. These values were both significantly higher than that of 2.25 +/- .97 pmole 5-HT/10(7) cells/min for normal children. The Km values of the three groups were not significantly different. Data on the five pairs of twins examined suggested that the elevated Vmax of 5-HT uptake by platelets was determined genetically.

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Year:  1986        PMID： 3957859     DOI： 10.1007/bf01531579

Source DB:  PubMed          Journal:  J Autism Dev Disord        ISSN： 0162-3257


  16 in total

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4.  Increased blood serotonin and platelets in early infantile autism.

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6.  Comparisons of serotonin uptake by blood platelets and brain synaptosomes.

Authors:  L T Smith; D R Hanson; G S Omenn
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Authors:  A Yuwiler; E Ritvo; E Geller; R Glousman; G Schneiderman; D Matsuno
Journal:  J Autism Child Schizophr       Date:  1975-06

8.  Electrodermal activity in depression: clinical and biochemical correlates.

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9.  Uptake of 5-hydroxytryptamine by isolated platelets in childhood schizophrenia and autism.

Authors:  D V Siva Sankar
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10.  Serotonin uptake in blood platelets of psychiatric patients.

Authors:  H Y Meltzer; R C Arora; R Baber; B J Tricou
Journal:  Arch Gen Psychiatry       Date:  1981-12
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  8 in total

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6.  Leveraging blood serotonin as an endophenotype to identify de novo and rare variants involved in autism.

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7.  Modeling rare gene variation to gain insight into the oldest biomarker in autism: construction of the serotonin transporter Gly56Ala knock-in mouse.

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8.  Origin of the blood hyperserotonemia of autism.

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  8 in total

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