| Literature DB >> 2708296 |
R B Minderaa1, G M Anderson, F R Volkmar, D Harcherick, G W Akkerhuis, D J Cohen.
Abstract
Whole blood serotonin (5-HT) was significantly increased in a drug-free autistic group (n = 17) compared to age- and sex-matched normal control (n = 20). Blood tryptophan (TRP) values and platelet counts were similar in unmedicated autistics and normal subjects; but whole blood concentrations of TRP were significantly lower, and 5-HT values tended to be lower in the medicated group compared to unmedicated autistics. Highly significant intraclass correlation coefficients and low mean percentage differences were found for repeated measures over a year's period of whole blood 5-HT and the platelet count in the unmedicated but not in the medicated group. Blood TRP values were highly variable over time in both the medicated and drug-free autistic groups.Entities:
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Year: 1989 PMID： 2708296 DOI： 10.1007/BF02212724
Source DB: PubMed Journal: J Autism Dev Disord ISSN： 0162-3257