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Literature DB >> 395415

Mitochondrial and nuclear mutations that affect the biogenesis of the mitochondrial ribosomes of yeast. II. Biochemistry.

Abstract

1. Several nuclear mutants have been isolated which showed thermo- or cryo-sensitive growth on non-fermentable media. Although the original strain carried mitochondrial drug resistance mutations (CR, ER, OR and PR), the resistance to one or several drugs was suppressed in these mutants. Two of them showed a much reduced amount of the mitochondrial small ribosomal subunit (37S) and of the corresponding 16S ribosomal RNA. Two dimensional electrophoretic analysis did not reveal any change in the position of any of the mitochondrial ribosomal proteins. However one of the mitochondrial ribosomal proteins. However one of the mutants showed a striking decrease in the amounts of three ribosomal proteins S3, S4 and S15. 2. Four temperature-sensitive mitochondrial mutations have been localized in the region of the gene coding for the large mitochondrial ribosomal RNA (23S). These mutants all showed a marked anomaly in the mitochondrial large ribosomal subunit (50S) and/or the corresponding 23S ribosomal RNA.

Entities: Disease Species

Mesh：

Substances：

Year: 1979 PMID： 395415 DOI： 10.1007/bf00267252

Source DB: PubMed Journal: Mol Gen Genet ISSN： 0026-8925

20 in total

1. Localization of the gene coding for the mitochondrial 16 S ribosomal RNA using rho- mutants of Saccharomyces cerevisiae.

Authors: G Faye; C Kujawa; B Dujon; M Bolotin-Fukuhara; K Wolf; H Fukuhara; P P Slonimski
Journal: J Mol Biol Date: 1975-11-25 Impact factor: 5.469

2. Nuclear suppressors of the [poky] cytoplasmic mutant in Neurospora crassa. III. Effects on other cytoplasmic mutants and on mitochondrial ribosome assembly in [poky].

Authors: R A Collins; H Bertrand
Journal: Mol Gen Genet Date: 1978-05-31

3. Variant forms of mitochondrial translation products in yeast: evidence for location of determinants on mitochondrial DNA.

Authors: M G Douglas; R A Butow
Journal: Proc Natl Acad Sci U S A Date: 1976-04 Impact factor: 11.205

4. Mutations of the mitochondrial DNA of Saccharomyces cerevisiae which affect the interaction between mitochondrial ribosomes and the inner mitochondrial membrane.

Authors: T W Spithill; M K Trembath; H B Lukins; A W Linnane
Journal: Mol Gen Genet Date: 1978-08-17

5. Biogenesis of mitochondria 49 identification and mapping of a new mitochondrial locus (tsr1) which maps within polar region of yeast mitochondrial genome.

Authors: R J Devenish; K J Englisn; R M Hall; A W Linnase; H B Lukins
Journal: Mol Gen Genet Date: 1978-05-31

6. An insert in the single gene for the large ribosomal RNA in yeast mitochondrial DNA.

Authors: J L Bos; C Heyting; P Borst; A C Arnberg; E F Van Bruggen
Journal: Nature Date: 1978-09-28 Impact factor: 49.962

7. Nucleotide sequence of a mutant eukaryotic gene: the yeast tyrosine-inserting ochre suppressor SUP4-o.

Authors: H M Goodman; M V Olson; B D Hall
Journal: Proc Natl Acad Sci U S A Date: 1977-12 Impact factor: 11.205

8. Physical and genetic organization of petite and grande yeast mitochondrial DNA.I. Studies by RNA-DNA hybridization.

Authors: H Fukuhara; G Faye; F Michel; J Lazowska; J Deutsch; M Bolotin-Fukuhara; P P slonimski
Journal: Mol Gen Genet Date: 1974-05-31

9. Mitochondrial antibiotic resistance in yeast: ribosomal mutants resistant to chloramphenicol, erythromycin and spiramycin.

Authors: L A Grivell; P Netter; P Borst; P P Slonimski
Journal: Biochim Biophys Acta Date: 1973-06-23

10. Physical and genetic organization of petite and grande yeast mitochondrial DNA. IV. In vivo transcription products of mitochondrial DNA and localization of 23 S ribosomal RNA in petite mutants of saccharomyces cerevisiae.

Authors: G Faye; C Kujawa; H Fukuhara
Journal: J Mol Biol Date: 1974-09-05 Impact factor: 5.469

11 in total

1. Second-site antibiotic resistance mutations in the ribosomal region of yeast mitochondrial DNA.

Authors: J A Knight; A J Courey; B Stebbins
Journal: Curr Genet Date: 1982-05 Impact factor: 3.886

2. Mitochondrial and nuclear mitoribosomal suppressors that enable misreading of ochre codons in yeast mitochondria : I. Isolation, localization and allelism of suppressors.

Authors: A Kruszewska; P P Slonimski
Journal: Curr Genet Date: 1984-12 Impact factor: 3.886

6. Genetics of mitochondrial ribosomes of yeast: mitochondrial lethality of a double mutant carrying two mutations of the 21S ribosomal RNA gene.

Authors: C Julou; M Bolotin-Fukuhara
Journal: Mol Gen Genet Date: 1982

Mitochondrial and nuclear mutations that affect the biogenesis of the mitochondrial ribosomes of yeast. II. Biochemistry.

1. Localization of the gene coding for the mitochondrial 16 S ribosomal RNA using rho- mutants of Saccharomyces cerevisiae.

2. Nuclear suppressors of the [poky] cytoplasmic mutant in Neurospora crassa. III. Effects on other cytoplasmic mutants and on mitochondrial ribosome assembly in [poky].

3. Variant forms of mitochondrial translation products in yeast: evidence for location of determinants on mitochondrial DNA.

4. Mutations of the mitochondrial DNA of Saccharomyces cerevisiae which affect the interaction between mitochondrial ribosomes and the inner mitochondrial membrane.

5. Biogenesis of mitochondria 49 identification and mapping of a new mitochondrial locus (tsr1) which maps within polar region of yeast mitochondrial genome.

6. An insert in the single gene for the large ribosomal RNA in yeast mitochondrial DNA.

7. Nucleotide sequence of a mutant eukaryotic gene: the yeast tyrosine-inserting ochre suppressor SUP4-o.

8. Physical and genetic organization of petite and grande yeast mitochondrial DNA.I. Studies by RNA-DNA hybridization.

9. Mitochondrial antibiotic resistance in yeast: ribosomal mutants resistant to chloramphenicol, erythromycin and spiramycin.

10. Physical and genetic organization of petite and grande yeast mitochondrial DNA. IV. In vivo transcription products of mitochondrial DNA and localization of 23 S ribosomal RNA in petite mutants of saccharomyces cerevisiae.

1. Second-site antibiotic resistance mutations in the ribosomal region of yeast mitochondrial DNA.

2. Mitochondrial and nuclear mitoribosomal suppressors that enable misreading of ochre codons in yeast mitochondria : I. Isolation, localization and allelism of suppressors.

3. A poliovirus temperature-sensitive RNA synthesis mutant located in a noncoding region of the genome.

4. Mitochondrial and nuclear mutations that affect the biogenesis of the mitochondrial ribosomes of yeast. I. Genetics.

5. A mitochondrial ribosomal RNA mutation and its nuclear suppressors.

6. Genetics of mitochondrial ribosomes of yeast: mitochondrial lethality of a double mutant carrying two mutations of the 21S ribosomal RNA gene.

Review 7. PET genes of Saccharomyces cerevisiae.

8. Mutational study of the rRNA in yeast mitochondria: functional importance of T1696 in the large rRNA gene.

9. Nature of an inserted sequence in the mitochondrial gene coding for the 15S ribosomal RNA of yeast.

10. Mitochondrial ribosomal RNA genes of yeast: their mutations and a common nuclear suppressor.