| Literature DB >> 3950618 |
R N Martins, C G Harper, G B Stokes, C L Masters.
Abstract
The activities of the hexose monophosphate pathway enzymes glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase were measured at autopsy in control and Alzheimer's disease brains. Enzyme activities did not vary between different areas of brain and were unaltered by age. In Alzheimer's disease, the activities of both enzymes were increased, the glucose-6-phosphate dehydrogenase activity being almost double the activity of normal controls. We propose that this increased enzyme activity is a response to elevated brain peroxide metabolism.Entities:
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Year: 1986 PMID： 3950618 DOI： 10.1111/j.1471-4159.1986.tb00615.x
Source DB: PubMed Journal: J Neurochem ISSN： 0022-3042 Impact factor: 5.372