| Literature DB >> 3950582 |
E A Gould, A Buckley, A D Barrett, N Cammack.
Abstract
The capacity of monoclonal antibodies to protect mice passively against yellow fever (YF) virus infection was investigated. Both neutralizing (54K-specific) and non-neutralizing (54K- and 48K-specific) antibodies protected mice against challenge with the RMP substrain of YF virus. Average survival times of mice inoculated intracerebrally with a standard lethal dose of YF virus differed according to the strain used: thus mice inoculated with the most neurovirulent viruses, FNV and Asibi, survived for 6 X 50 and 7 X 65 days respectively, and those with RMP virus survived for 15 X 75 days. The capacity of antibodies to protect mice passively against virus challenge was directly related to virus neurovirulence. Possible mechanisms and the significance of protection by antibodies against non-structural proteins that do not mediate neutralization, are discussed.Entities:
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Year: 1986 PMID： 3950582 DOI： 10.1099/0022-1317-67-3-591
Source DB: PubMed Journal: J Gen Virol ISSN： 0022-1317 Impact factor: 3.891