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Literature DB >> 3950546

Immunoglobulin with complementary paratope and idiotope.

Abstract

A hybridoma antibody (11E7-1) was isolated from a myeloma fusion with nu/nu BALB/c immunized against the T15 idiotype. This IgM antibody exhibited a dual specificity, binding both to PC and to anti-PC antibodies from two idiotype families. Binding to PC and anti-PC antibodies are completely inhibited by PC analogs. Furthermore, the hybridoma antibody binds to itself. Self-binding is also inhibited by PC analogs. From these data, we suggest that 11E7-1 hybridoma antibody has a PC-specific paratope site, and at same time expresses the internal PC antigen idiotope. The term autobody is proposed to signify its self-binding and potential role in autoimmunity. Autobodies may have a unique role in the network of immune system. Furthermore, it may be a model for designing idiotype vaccines.

Entities: Disease

Mesh：

Substances：

Year: 1986 PMID： 3950546 PMCID： PMC2188074 DOI： 10.1084/jem.163.4.787

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

17 in total

Review 1. Rational design and application of idiotope vaccines.

Authors: T Kieber-Emmons; R E Ward; S Raychaudhuri; R Rein; H Kohler
Journal: Int Rev Immunol Date: 1986-01 Impact factor: 5.311

2. Speculations on idiotypes and homobodies.

Authors: J Lindenmann
Journal: Ann Immunol (Paris) Date: 1973-05

Review 3. An immunologic network.

Authors: D A Rowley; H Köhler; J D Cowan
Journal: Contemp Top Immunobiol Date: 1980

4. Towards a network theory of the immune system.

Authors: N K Jerne
Journal: Ann Immunol (Paris) Date: 1974-01

5. Antiphosphocholine antibodies found in normal mouse serum are protective against intravenous infection with type 3 streptococcus pneumoniae.

Authors: D E Briles; M Nahm; K Schroer; J Davie; P Baker; J Kearney; R Barletta
Journal: J Exp Med Date: 1981-03-01 Impact factor: 14.307

6. The three-dimensional structure of a phosphorylcholine-binding mouse immunoglobulin Fab and the nature of the antigen binding site.

Authors: D M Segal; E A Padlan; G H Cohen; S Rudikoff; M Potter; D R Davies
Journal: Proc Natl Acad Sci U S A Date: 1974-11 Impact factor: 11.205

7. Immune response to phosphorylcholine. IX. Characterization of hybridoma anti-TEPC15 antibodies.

Authors: M K Wittner; M A Bach; H Köhler
Journal: J Immunol Date: 1982-02 Impact factor: 5.422

8. Recurrent idiotopes and internal images.

Authors: N K Jerne; J Roland; P A Cazenave
Journal: EMBO J Date: 1982 Impact factor: 11.598

9. An analysis of the sequences of the variable regions of Bence Jones proteins and myeloma light chains and their implications for antibody complementarity.

Authors: T T Wu; E A Kabat
Journal: J Exp Med Date: 1970-08-01 Impact factor: 14.307

10. Anti-immunoglobulin antibodies. III. Properties of sequential anti-idiotypic antibodies to heterologous anti-gamma globulins. Detection of reactivity of anti-idiotype antibodies with epitopes of Fc fragments (homobodies) and with epitopes and idiotopes (epibodies).

Authors: C A Bona; S Finley; S Waters; H G Kunkel
Journal: J Exp Med Date: 1982-10-01 Impact factor: 14.307

8 in total

1. Immune networks modeled by replicator equations.

Authors: P F Stadler; P Schuster; A S Perelson
Journal: J Math Biol Date: 1994 Impact factor: 2.259

2. Immune network behavior--II. From oscillations to chaos and stationary states.

Authors: R J De Boer; A S Perelson; I G Kevrekidis
Journal: Bull Math Biol Date: 1993 Impact factor: 1.758

3. Human anti-phosphorylcholine antibodies share idiotopes and are self-binding.

Authors: R Halpern; S V Kaveri; H Köhler
Journal: J Clin Invest Date: 1991-08 Impact factor: 14.808

4. Antibodies with idiotypic and anti-idiotypic reactivity (epibodies) in conventional immune responses to dinitrophenylated carriers.

Authors: L Muhumuza; D Segre; M Segre
Journal: Immunology Date: 1998-04 Impact factor: 7.397