Literature DB >> 3949398

Detection of 2,5-hexanedione in the urine of persons not exposed to n-hexane.

N Fedtke, H M Bolt.   

Abstract

The neurotoxic n-hexane metabolite 2,5-hexanedione was detected by gas chromatography--mass spectrometry in urine samples from human subjects not exposed to n-hexane or related hydrocarbons. Quantitative determinations by multiple ion detection revealed an amount of 2,5-hexanedione ranging from 0.12 to 0.78 mg/l (0.45 +/- 0.20 mg/l; means +/- SD). The amounts of 2,5-hexanedione actually measured in urinary extracts depended on the pH employed for acid hydrolysis of the samples.

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Year:  1986        PMID： 3949398     DOI： 10.1007/bf00381382

Source DB:  PubMed          Journal:  Int Arch Occup Environ Health        ISSN： 0340-0131            Impact factor:   3.015


  18 in total

1.  Characterization of the metabolites of methyl n-butyl ketone, methyl iso-butyl ketone, and methyl ethyl ketone in guinea pig serum and their clearance.

Authors:  G D DiVincenzo; C J Kaplan; J Dedinas
Journal:  Toxicol Appl Pharmacol       Date:  1976-06       Impact factor: 4.219

2.  Dose-dependent uptake, distribution, and elimination of inhaled n-hexane in the Fischer-344 rat.

Authors:  T S Baker; D E Rickert
Journal:  Toxicol Appl Pharmacol       Date:  1981-12       Impact factor: 4.219

3.  Age-related changes in lipid peroxidation as measured by ethane, ethylene, butane and pentane in respired gases of rats.

Authors:  M Sagai; T Ichinose
Journal:  Life Sci       Date:  1980-09-01       Impact factor: 5.037

4.  Urinary excretion of the metabolites of n-hexane and its isomers during occupational exposure.

Authors:  L Perbellini; F Brugnone; G Faggionato
Journal:  Br J Ind Med       Date:  1981-02

5.  Methodological investigations on the determination of n-hexane metabolites in urine.

Authors:  N Fedtke; H M Bolt
Journal:  Int Arch Occup Environ Health       Date:  1986       Impact factor: 3.015

6.  Alterations in rat axonal cytoskeletal proteins induced by in vitro and in vivo 2,5-hexanedione exposure.

Authors:  A P DeCaprio; E A O'Neill
Journal:  Toxicol Appl Pharmacol       Date:  1985-04       Impact factor: 4.219

7.  Changes of n-hexane metabolites in urine of rats exposed to various concentrations of n-hexane and to its mixture with toluene or MEK.

Authors:  M Iwata; Y Takeuchi; N Hisanaga; Y Ono
Journal:  Int Arch Occup Environ Health       Date:  1983       Impact factor: 3.015

8.  Measurement of the urinary metabolites of N-hexane, cyclohexane and their isomers by gas chromatography.

Authors:  L Perbellini; F Brugnone; R Silvestri; E Gaffuri
Journal:  Int Arch Occup Environ Health       Date:  1981       Impact factor: 3.015

9.  Toxic polyneuropathy produced by methyl N-butyl ketone.

Authors:  J R Mendell; K Saida; M F Ganansia; D B Jackson; H Weiss; R W Gardier; C Chrisman; N Allen; D Couri; J O'Neill; B Marks; L Hetland
Journal:  Science       Date:  1974-08-30       Impact factor: 47.728

10.  n-Hexane metabolism in occupationally exposed workers.

Authors:  A Mutti; M Falzoi; S Lucertini; G Arfini; M Zignani; S Lombardi; I Franchini
Journal:  Br J Ind Med       Date:  1984-11
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  14 in total

1.  The method of choice for the determination of 2,5-hexanedione as an indicator of occupational exposure to n-hexane.

Authors:  T Kawai; K Mizunuma; T Yasugi; Y Uchida; M Ikeda
Journal:  Int Arch Occup Environ Health       Date:  1990       Impact factor: 3.015

2.  An improved method of analysing 2,5-hexanedione in urine.

Authors:  L Perbellini; D M Marhuenda Amoros; A C Cardona Llorens; C Giuliari; F Brugnone
Journal:  Br J Ind Med       Date:  1990-06

3.  Spectrophotometric determination of pyrrole-like substances in urine of rat and man: an assay for the evaluation of 2,5-hexanedione formed from n-hexane.

Authors:  W Kessler; H Heilmaier; P Kreuzer; J H Shen; M Filser; J G Filser
Journal:  Arch Toxicol       Date:  1990       Impact factor: 5.153

4.  Biochemical and physiological aspects of 2,5-hexanedione: endogenous or exogenous product?

Authors:  L Perbellini; G Pezzoli; F Brugnone; M Canesi
Journal:  Int Arch Occup Environ Health       Date:  1993       Impact factor: 3.015

5.  On the need of a sampling strategy in biological monitoring: the example of hexane exposure.

Authors:  A Mutti; E Bergamaschi; S Ghittori; M Imbriani; I Franchini
Journal:  Int Arch Occup Environ Health       Date:  1993       Impact factor: 3.015

6.  Determination of urinary 2,5-hexanedione concentration by an improved analytical method as an index of exposure to n-hexane.

Authors:  I Saito; E Shibata; J Huang; N Hisanaga; Y Ono; Y Takeuchi
Journal:  Br J Ind Med       Date:  1991-08

7.  2-Acetylfuran, a confounder in urinalysis for 2,5-hexanedione as an n-hexane exposure indicator.

Authors:  T Kawai; T Yasugi; K Mizunuma; S Horiguchi; Y Uchida; O Iwami; H Iguchi; M Ikeda
Journal:  Int Arch Occup Environ Health       Date:  1991       Impact factor: 3.015

8.  Ubiquitous pollution by n-hexane and reference biological levels in the general population.

Authors:  F Brugnone; G Maranelli; L Romeo; C Giuliari; M Gobbi; F Malesani; G Bassi; C Alexopoulos
Journal:  Int Arch Occup Environ Health       Date:  1991       Impact factor: 3.015

9.  The relevance of 4,5-dihydroxy-2-hexanone in the excretion kinetics of n-hexane metabolites in rat and man.

Authors:  N Fedtke; H M Bolt
Journal:  Arch Toxicol       Date:  1987-12       Impact factor: 5.153

10.  Dose-dependent increase in 2,5-hexanedione in the urine of workers exposed to n-hexane.

Authors:  T Kawai; T Yasugi; K Mizunuma; S Horiguchi; Y Uchida; O Iwami; H Iguchi; M Ikeda
Journal:  Int Arch Occup Environ Health       Date:  1991       Impact factor: 3.015
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