Literature DB >> 2378820

An improved method of analysing 2,5-hexanedione in urine.

L Perbellini1, D M Marhuenda Amoros, A C Cardona Llorens, C Giuliari, F Brugnone.   

Abstract

A short gas-chromatographic method for analysing urinary concentrations of 2,5-hexanedione is based on acid hydrolysis of urine at pH below 0.1 and "purification" of the urine samples by microcolumns containing an octadecyl-silane phase. A 5% acetonitrile solution allows a fairly selective elution of 2,5-hexanedione from the microcolumns. Recovery of 2,5-hexanedione from urine is as great as 79.9%. The variation coefficient of the measurements is 2.8%. The results obtained from different working conditions and using packed or wide bore or capillary gas-chromatographic columns are reported.

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Year:  1990        PMID： 2378820      PMCID： PMC1035195          DOI： 10.1136/oem.47.6.421

Source DB:  PubMed          Journal:  Br J Ind Med        ISSN： 0007-1072


  10 in total

1.  [Gas chromatographic determination of 2,5-hexanedione in the urine].

Authors:  L Perbellini; F Tagliaro; S Maschio; A Zedde; F Brugnone
Journal:  Med Lav       Date:  1986 Nov-Dec       Impact factor: 1.275

2.  2,5-Hexanedione excretion after occupational exposure to n-hexane.

Authors:  I Ahonen; R W Schimberg
Journal:  Br J Ind Med       Date:  1988-02

3.  [2,5-hexanedione in biological monitoring of occupational exposure to n-hexane].

Authors:  L Perbellini; G B Bartolucci; F Brugnone; E De Rosa; F Valentini
Journal:  Med Lav       Date:  1985 Jan-Feb       Impact factor: 1.275

4.  Urinary excretion of the metabolites of n-hexane and its isomers during occupational exposure.

Authors:  L Perbellini; F Brugnone; G Faggionato
Journal:  Br J Ind Med       Date:  1981-02

5.  A study on biological monitoring of n-hexane exposure.

Authors:  M Iwata; Y Takeuchi; N Hisanaga; Y Ono
Journal:  Int Arch Occup Environ Health       Date:  1983       Impact factor: 3.015

6.  Detection of 2,5-hexanedione in the urine of persons not exposed to n-hexane.

Authors:  N Fedtke; H M Bolt
Journal:  Int Arch Occup Environ Health       Date:  1986       Impact factor: 3.015

7.  Methodological investigations on the determination of n-hexane metabolites in urine.

Authors:  N Fedtke; H M Bolt
Journal:  Int Arch Occup Environ Health       Date:  1986       Impact factor: 3.015

8.  The relevance of 4,5-dihydroxy-2-hexanone in the excretion kinetics of n-hexane metabolites in rat and man.

Authors:  N Fedtke; H M Bolt
Journal:  Arch Toxicol       Date:  1987-12       Impact factor: 5.153

9.  Measurement of the urinary metabolites of N-hexane, cyclohexane and their isomers by gas chromatography.

Authors:  L Perbellini; F Brugnone; R Silvestri; E Gaffuri
Journal:  Int Arch Occup Environ Health       Date:  1981       Impact factor: 3.015

10.  n-Hexane metabolism in occupationally exposed workers.

Authors:  A Mutti; M Falzoi; S Lucertini; G Arfini; M Zignani; S Lombardi; I Franchini
Journal:  Br J Ind Med       Date:  1984-11
  10 in total
  7 in total

1.  Behaviour of urinary 2,5-hexanedione in occupational co-exposure to n-hexane and acetone.

Authors:  A Cardona; D Marhuenda; M J Prieto; J Martí; J F Periago; J M Sánchez
Journal:  Int Arch Occup Environ Health       Date:  1996       Impact factor: 3.015

2.  Biochemical and physiological aspects of 2,5-hexanedione: endogenous or exogenous product?

Authors:  L Perbellini; G Pezzoli; F Brugnone; M Canesi
Journal:  Int Arch Occup Environ Health       Date:  1993       Impact factor: 3.015

3.  Biological monitoring of occupational exposure to n-hexane by exhaled air analysis and urinalysis.

Authors:  J F Periago; A Cardona; D Marhuenda; J Roel; M Villanueva; J Marti; A Luna
Journal:  Int Arch Occup Environ Health       Date:  1993       Impact factor: 3.015

4.  On the need of a sampling strategy in biological monitoring: the example of hexane exposure.

Authors:  A Mutti; E Bergamaschi; S Ghittori; M Imbriani; I Franchini
Journal:  Int Arch Occup Environ Health       Date:  1993       Impact factor: 3.015

5.  Biological monitoring of occupational exposure to n-hexane by measurement of urinary 2,5-hexanedione.

Authors:  A Cardona; D Marhuenda; J Martí; F Brugnone; J Roel; L Perbellini
Journal:  Int Arch Occup Environ Health       Date:  1993       Impact factor: 3.015

6.  Determination of urinary 2,5-hexanedione concentration by an improved analytical method as an index of exposure to n-hexane.

Authors:  I Saito; E Shibata; J Huang; N Hisanaga; Y Ono; Y Takeuchi
Journal:  Br J Ind Med       Date:  1991-08

7.  Urinary 2,5-hexanedione excretion in cryptogenic polyneuropathy compared to the general Swedish population.

Authors:  Bodil Persson; Magnus Vrethem; Nicola Murgia; Jonas Lindh; Anna-Lena Hällsten; Mats Fredrikson; Martin Tondel
Journal:  J Occup Med Toxicol       Date:  2013-07-30       Impact factor: 2.646
  7 in total

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