Literature DB >> 3948148

Prediction of human tumor cell chemosensitivity using the sister chromatid exchange assay.

D F Deen, L E Kendall, L J Marton, P J Tofilon.   

Abstract

The sister chromatid exchange (SCE) assay has been used to predict the chemosensitivity to 1,3-bis(2-chloroethyl)-1-nitrosourea of various neoplastic cell subpopulations in eight cell lines derived from human brain tumors. Because the SCE assay is based on analysis of individual cells, data obtained can be plotted as frequency histograms of SCEs per chromosome, and the range of chemosensitivities of cell subpopulations can be identified easily. Results suggest that the SCE assay has predictive value as a clinical assay for drugs for which a strong correlation between cell kill and induction of SCEs has been established.

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Year:  1986        PMID： 3948148

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  8 in total

1.  In silico prediction of chemical genotoxicity using machine learning methods and structural alerts.

Authors:  Defang Fan; Hongbin Yang; Fuxing Li; Lixia Sun; Peiwen Di; Weihua Li; Yun Tang; Guixia Liu
Journal:  Toxicol Res (Camb)       Date:  2017-12-15       Impact factor: 3.524

2.  Chemotherapy for malignant gliomas of the brain: a review of ten-years experience.

Authors:  P Paoletti; G Butti; R Knerich; P Gaetani; R Assietti
Journal:  Acta Neurochir (Wien)       Date:  1990       Impact factor: 2.216

3.  Molecular cloning of protein 4.1, a major structural element of the human erythrocyte membrane skeleton.

Authors:  J Conboy; Y W Kan; S B Shohet; N Mohandas
Journal:  Proc Natl Acad Sci U S A       Date:  1986-12       Impact factor: 11.205

4.  Human placental Na+,K+-ATPase alpha subunit: cDNA cloning, tissue expression, DNA polymorphism, and chromosomal localization.

Authors:  F F Chehab; Y W Kan; M L Law; J Hartz; F T Kao; R Blostein
Journal:  Proc Natl Acad Sci U S A       Date:  1987-11       Impact factor: 11.205

5.  Time course changes of anti- and pro-apoptotic proteins in apigenin-induced genotoxicity.

Authors:  Fotini Papachristou; Ekaterini Chatzaki; Athanasios Petrou; Ioanna Kougioumtzi; Nikolaos Katsikogiannis; Alexandros Papalambros; Grigorios Tripsianis; Constantinos Simopoulos; Alexandra K Tsaroucha
Journal:  Chin Med       Date:  2013-05-04       Impact factor: 5.455

6.  Heterogeneity in radiation sensitivity within human primary tumour cell cultures as detected by the SCE assay.

Authors:  P J Tofilon; C M Vines; R E Meyn; J Wike; W A Brock
Journal:  Br J Cancer       Date:  1989-01       Impact factor: 7.640

7.  Serial measurement of sister chromatid exchanges in the peripheral lymphocytes of patients with lung cancer receiving chemotherapy in relation to bone marrow toxicity.

Authors:  T Shinkai; N Saijo; K Eguchi; Y Sasaki; T Tamura; Y Fujiwara; A Kojima; K Nakagawa; K Minato; T Nakajima
Journal:  Jpn J Cancer Res       Date:  1989-08

8.  Inhibitory effects of sizofiran on anticancer agent- or X-ray-induced sister chromatid exchanges and mitotic block in murine bone marrow cells.

Authors:  Z B Yang; Y Tsuchiya; T Arika; M Hosokawa
Journal:  Jpn J Cancer Res       Date:  1993-05
  8 in total

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