Literature DB >> 3945725

The in vitro radiobiology of astatine-211 decay.

A I Kassis, C R Harris, S J Adelstein, T J Ruth, R Lambrecht, A P Wolf.   

Abstract

Chinese hamster V79 cells in culture were exposed to astatine-211, an alpha-particle-emitting radiohalogen. The dose-log survival response was linear with no detectable shoulder. Cells in monolayers had a D0 of 1.0 microCi/ml. Suspended cells had a D0 of 0.60 microCi/ml with a cellular uptake of 2.5 fCi/cell; this is equal to approximately 1.5 alpha-particle traversals per cell nucleus. The frequencies of chromosome and chromatid breaks were linear with dose, but the number declined rapidly with time. These data are discussed in relation to published alpha-particle beam studies and the potential use of 211At in radionuclide therapy.

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Year:  1986        PMID： 3945725

Source DB:  PubMed          Journal:  Radiat Res        ISSN： 0033-7587            Impact factor:   2.841


  12 in total

Review 1.  The biology of the sodium iodide symporter and its potential for targeted gene delivery.

Authors:  Mohan Hingorani; Christine Spitzweg; Georges Vassaux; Kate Newbold; Alan Melcher; Hardev Pandha; Richard Vile; Kevin Harrington
Journal:  Curr Cancer Drug Targets       Date:  2010-03       Impact factor: 3.428

2.  In-vivo radiotoxicity of DNA-incorporated 125I compared with that of densely ionising alpha-particles.

Authors:  D V Rao; V R Narra; R W Howell; G F Govelitz; K S Sastry
Journal:  Lancet       Date:  1989-09-16       Impact factor: 79.321

3.  Biological effect of lead-212 localized in the nucleus of mammalian cells: role of recoil energy in the radiotoxicity of internal alpha-particle emitters.

Authors:  M T Azure; R D Archer; K S Sastry; D V Rao; R W Howell
Journal:  Radiat Res       Date:  1994-11       Impact factor: 2.841

4.  Radiotoxicity of gadolinium-148 and radium-223 in mouse testes: relative biological effectiveness of alpha-particle emitters in vivo.

Authors:  R W Howell; S M Goddu; V R Narra; D R Fisher; R E Schenter; D V Rao
Journal:  Radiat Res       Date:  1997-03       Impact factor: 2.841

5.  Labeling monoclonal antibodies and F(ab')2 fragments with the alpha-particle-emitting nuclide astatine-211: preservation of immunoreactivity and in vivo localizing capacity.

Authors:  M R Zalutsky; P K Garg; H S Friedman; D D Bigner
Journal:  Proc Natl Acad Sci U S A       Date:  1989-09       Impact factor: 11.205

Review 6.  Therapeutic radionuclides: biophysical and radiobiologic principles.

Authors:  Amin I Kassis
Journal:  Semin Nucl Med       Date:  2008-09       Impact factor: 4.446

Review 7.  Targeted and Nontargeted α-Particle Therapies.

Authors:  Michael R McDevitt; George Sgouros; Stavroula Sofou
Journal:  Annu Rev Biomed Eng       Date:  2018-01-18       Impact factor: 9.590

8.  Microdosimetric analysis of 211At in thyroid models for man, rat and mouse.

Authors:  Anders Josefsson; Eva Forssell-Aronsson
Journal:  EJNMMI Res       Date:  2012-06-09       Impact factor: 3.138

9.  Intratumour injection of immunoglobulins labelled with the alpha-particle emitter 211At: analyses of tumour retention, microdistribution and growth delay.

Authors:  R H Larsen; O S Bruland
Journal:  Br J Cancer       Date:  1998-04       Impact factor: 7.640

10.  Radiotoxicity of platinum-195m-labeled trans-platinum (II) in mammalian cells.

Authors:  R W Howell; A I Kassis; S J Adelstein; D V Rao; H A Wright; R N Hamm; J E Turner; K S Sastry
Journal:  Radiat Res       Date:  1994-10       Impact factor: 3.372
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