Literature DB >> 3939868

Mycotoxin induction of somatic mosaicism in Drosophila and DNA repair in mammalian liver cell cultures.

G A Belitsky1, E M Khovanova, I V Budunova, H G Sharuptis.   

Abstract

The genotoxic activity of four mycotoxins has been studied. A high level of somatic mutagenesis in imaginal disk of Drosophila melanogaster larvae and DNA repair synthesis in human embryo and adult rat liver cells cultures was induced only by the strong carcinogen aflatoxin B1. Patulin somewhat elevated the level of somatic mutations in D. melanogaster, but did not elicit DNA repair synthesis. Citrinin and stachybotryotoxin were inactive in both systems.

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Year:  1985        PMID： 3939868     DOI： 10.1007/bf00120160

Source DB:  PubMed          Journal:  Cell Biol Toxicol        ISSN： 0742-2091            Impact factor:   6.691


  24 in total

1.  [Somatic mutagenesis in D. melanogaster as an express method of testing carcinogens (N-nitroso compounds)].

Authors:  L M Shabad; E M Khovanova; E G Logvinenko; G A Belitskiĭ
Journal:  Dokl Akad Nauk SSSR       Date:  1976-12-01

2.  Differential induction of altered gene expression by carcinogens at mutant alleles of a Drosophila locus with a transposable element.

Authors:  M J Fahmy; O G Fahmy
Journal:  Cancer Res       Date:  1983-02       Impact factor: 12.701

3.  Detection of chemical carcinogens by unscheduled DNA synthesis in rat liver primary cell cultures.

Authors:  G M Williams
Journal:  Cancer Res       Date:  1977-06       Impact factor: 12.701

4.  Long-term testing of patulin administered orally to Sprague-Dawley rats and Swiss mice.

Authors:  H Osswald; H K Frank; D Komitowski; H Winter
Journal:  Food Cosmet Toxicol       Date:  1978-06

5.  Patulin, a further clastogenic mycotoxin, is negative in the SCE assay in Chinese hamster V79-E cells in vitro.

Authors:  R Thust; S Kneist; J Mendel
Journal:  Mutat Res       Date:  1982-01       Impact factor: 2.433

6.  Combination effect of citrinin and other chemicals on rat kidney tumorigenesis.

Authors:  Y Shinohara; M Arai; K Hirao; S Sugihara; K Nakanishi
Journal:  Gan       Date:  1976-04

7.  Genotoxicity of a variety of mycotoxins in the hepatocyte primary culture/DNA repair test using rat and mouse hepatocytes.

Authors:  H Mori; K Kawai; F Ohbayashi; T Kuniyasu; M Yamazaki; T Hamasaki; G M Williams
Journal:  Cancer Res       Date:  1984-07       Impact factor: 12.701

8.  Tumorigenicity of citrinin in male F344 rats.

Authors:  M Arai; T Hibino
Journal:  Cancer Lett       Date:  1983-01       Impact factor: 8.679

9.  Mutagenicity and inducibility of DNA single-strand breaks and chromosome aberrations by various mycotoxins.

Authors:  M Umeda; T Tsutsui; M Saito
Journal:  Gan       Date:  1977-10

10.  Balkan (endemic) nephropathy and a toxin-producing strain of Penicillium verrucosum var cyclopium: An experimental model in rats.

Authors:  J M Barnes; P K Austwick; R L Carter; F V Flynn; G C Peristianis; W N Aldridge
Journal:  Lancet       Date:  1977-03-26       Impact factor: 79.321
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  2 in total

1.  Use of cell cultures for predicting the biological effects of mycotoxins.

Authors:  S Robbana-Barnat; C Lafarge-Frayssinet; C Frayssinet
Journal:  Cell Biol Toxicol       Date:  1989-06       Impact factor: 6.691

2.  Genotoxicity and carcinogenicity testing of 1,2-dibromopropane and 1,1,3-tribromopropane in comparison to 1,2-dibromo-3-chloropropane.

Authors:  G A Belitsky; T A Lytcheva; I A Khitrovo; R D Safaev; V S Zhurkov; I F Vyskubenko; L P Sytshova; O G Salamatova; E G Feldt; V V Khudoley
Journal:  Cell Biol Toxicol       Date:  1994-08       Impact factor: 6.691
  2 in total

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