Literature DB >> 3935563

Hunter syndrome among Ashkenazi Jews in Israel; evidence for prenatal selection favoring the Hunter allele.

J Zlotogora, T Schaap, M Zeigler, G Bach.   

Abstract

Analysis of Ashkenazi families with Hunter patients in Israel demonstrated the complete absence of new mutations among the probands' mothers. Furthermore, in these families a significant deviation of the segregation ratio between the Hunter gene and the normal allele was demonstrated among offspring of heterozygous mothers or siblings of affected children. This may be due to pre- or postzygotic prenatal selection, favoring the X chromosome carrying the Hunter gene among Ashkenazi Jews.

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Year:  1985        PMID： 3935563     DOI： 10.1007/bf00388459

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  9 in total

1.  The marker (X) syndrome: a cytogenetic and genetic analysis.

Authors:  S L Sherman; N E Morton; P A Jacobs; G Turner
Journal:  Ann Hum Genet       Date:  1984-01       Impact factor: 1.670

2.  Differences in the frequency of X-linked deleterious genes in human populations.

Authors:  A Chakravarti; S J Bale
Journal:  Am J Hum Genet       Date:  1983-11       Impact factor: 11.025

3.  Mutation and selection in the marker (X) syndrome. A hypothesis.

Authors:  F Vogel
Journal:  Ann Hum Genet       Date:  1984-10       Impact factor: 1.670

4.  Iduronate sulfatase in amniotic fluid: an aid in the prenatal diagnosis of the hunter syndrome.

Authors:  I Liebaers; P Di Natale; E F Neufeld
Journal:  J Pediatr       Date:  1977-03       Impact factor: 4.406

5.  A clinical and genetic study of Hunter's syndrome. 1. Heterogeneity.

Authors:  I D Young; P S Harper; I M Archer; R G Newcombe
Journal:  J Med Genet       Date:  1982-12       Impact factor: 6.318

6.  Incidence of mucopolysaccharidoses in Israel: is Hunter disease a "Jewish disease"?

Authors:  T Schaap; G Bach
Journal:  Hum Genet       Date:  1980       Impact factor: 4.132

7.  The occurrence of new mutants in the X-linked recessive Lesch-Nyhan disease.

Authors:  U Francke; J Felsenstein; S M Gartler; B R Migeon; J Dancis; J E Seegmiller; F Bakay; W L Nyhan
Journal:  Am J Hum Genet       Date:  1976-03       Impact factor: 11.025

8.  The use of fructose 1-phosphate to detect Hunter heterozygotes in fibroblast cultures from high-risk carriers.

Authors:  T Tønnesen
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

9.  Heterozygote detection in Hunter syndrome.

Authors:  J Zlotogora; G Bach
Journal:  Am J Med Genet       Date:  1984-03
  9 in total
  3 in total

1.  Medical genetics in Israel.

Authors:  R M Goodman; B Bonne-Tamir; A Adam; R Voss; G Bach; Y Shiloh; M B Katznelson; G Barkai; B Goldman; B Padeh
Journal:  J Med Genet       Date:  1989-03       Impact factor: 6.318

2.  Segregation and sporadic cases in families with Hunter's syndrome.

Authors:  G Machill; G Barbujani; G A Danieli; F H Herrmann
Journal:  J Med Genet       Date:  1991-06       Impact factor: 6.318

3.  Hunter syndrome in Jews in Israel: further evidence for prenatal selection favoring the Hunter allele.

Authors:  J Zlotogora; T Schaap; M Zeigler; G Bach
Journal:  Hum Genet       Date:  1991-03       Impact factor: 4.132
  3 in total

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