Literature DB >> 3934576

Mesolimbic dopamine lesions produce an augmented behavioral response to enkephalin.

P W Kalivas, M Bronson.   

Abstract

The mesolimbic dopamine (DA) system was lesioned by the injection of 6-hydroxydopamine into the nucleus accumbens or ventral tegmental area of rats. The rats were then examined in a photocell apparatus for their response to injection with the enkephalin analogue, D-Ala2-Met5-enkephalinamide (DALA), into the nucleus accumbens. Rats with DA lesions showed a significantly greater increase in photocell counts in response to DALA than did sham-lesioned animals. The potentiated motor response was dose-related, and rats having the greatest depletion of DA in the nucleus accumbens showed the greatest behavioral response to DALA. It was concluded that chronic impairment of dopaminergic innervation to the nucleus accumbens results in an enhanced response to DALA injected directly into the nucleus accumbens.

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Year:  1985        PMID： 3934576     DOI： 10.1016/0028-3908(85)90117-0

Source DB:  PubMed          Journal:  Neuropharmacology        ISSN： 0028-3908            Impact factor:   5.250


  13 in total

1.  Opioid delta agonists and endogenous enkephalins induce different emotional reactivity than mu agonists after injection in the rat ventral tegmental area.

Authors:  G Calenco-Choukroun; V Daugé; G Gacel; J Féger; B P Roques
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530

2.  Blockade of dopamine receptors reverses the behavioral effects of endogenous enkephalins in the Nucleus caudatus but not in the Nucleus accumbens: differential involvement of delta and mu opioid receptors.

Authors:  V Daugé; P Rossignol; B P Roques
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

3.  The effects of dopamine D1 and D2 receptor antagonists on the rewarding effects of delta 1 and delta 2 opioid receptor agonists in mice.

Authors:  T Suzuki; M Tsuji; T Mori; M Misawa; H Nagase
Journal:  Psychopharmacology (Berl)       Date:  1996-04       Impact factor: 4.530

4.  Morphine-induced hyperactivity in rats--a rebound effect?

Authors:  B Magnus-Ellenbroek; U Havemann-Reinecke
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-06       Impact factor: 3.000

5.  Dopamine depletion augments endogenous opioid-induced locomotion in the nucleus accumbens using both mu 1 and delta opioid receptors.

Authors:  L Churchill; B P Roques; P W Kalivas
Journal:  Psychopharmacology (Berl)       Date:  1995-08       Impact factor: 4.530

6.  Regional studies of serotonin and dopamine metabolism and quantification of serotonin uptake sites in human cerebral cortex.

Authors:  B Parsons; A Roxas; Y Y Huang; A Dwork; M Stanley
Journal:  J Neural Transm Gen Sect       Date:  1992

7.  Dopamine depletion reorganizes projections from the nucleus accumbens and ventral pallidum that mediate opioid-induced motor activity.

Authors:  L Churchill; M A Klitenick; P W Kalivas
Journal:  J Neurosci       Date:  1998-10-01       Impact factor: 6.167

8.  Mesoaccumbens dopamine-opiate interactions in the control over behaviour by a conditioned reinforcer.

Authors:  G D Phillips; T W Robbins; B J Everitt
Journal:  Psychopharmacology (Berl)       Date:  1994-03       Impact factor: 4.530

9.  Comparison of the behavioural effects induced by administration in rat nucleus accumbens or nucleus caudatus of selective mu and delta opioid peptides or kelatorphan an inhibitor of enkephalin-degrading-enzymes.

Authors:  V Daugé; P Rossignol; B P Roques
Journal:  Psychopharmacology (Berl)       Date:  1988       Impact factor: 4.530

10.  Role of mu- and delta-opioid receptors in the nucleus accumbens in cocaine-seeking behavior.

Authors:  Diana Simmons; David W Self
Journal:  Neuropsychopharmacology       Date:  2009-03-11       Impact factor: 7.853
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