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Literature DB >> 3934321

T cell receptor beta chain gene rearrangements in lymphoproliferative disorders of large granular lymphocytes/natural killer cells.

A Rambaldi, P G Pelicci, P Allavena, D M Knowles, S Rossini, R Bassan, T Barbui, R Dalla-Favera, A Mantovani.

Abstract

Twelve cases of T gamma LPD (lymphoproliferative disorders of Fc gamma receptor-bearing T cells) involving an expansion of large granular lymphocyte/natural killer (LGL/NK) cells were investigated for the expression of LGL/NK-associated markers and for T beta gene rearrangement. All the cases selected were classified as T gamma LPD on the basis of morphology, function, and phenotype of the circulating cells. 10 to 12 cases displayed clonal rearrangements of the T beta locus and expression of the T3 antigen, whereas the 2 remaining cases displayed the germline configuration of the T beta gene and no expression of the T3 antigen. T8, Mol, B73.1, and N901 antigens were variably expressed among both T beta+T3+ and T beta-T3- T gamma LPD cases. We suggest that individual T gamma LPD cases represent the clonal expansion of cells frozen at different stages of differentiation/activation within an individual hematopoietic LGL/NK lineage.

Entities: Disease Gene

Mesh：

Substances：

Year: 1985 PMID： 3934321 PMCID： PMC2187976 DOI： 10.1084/jem.162.6.2156

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

14 in total

1. Murine monoclonal antibodies as probes for the phenotypical, functional, and molecular analysis of a discrete peripheral blood lymphocyte population exerting natural killer activity in vitro.

Authors: F Malavasi; G Bellone; L Matera; C Milanese; E Ferrero; A Funaro; S Demaria; F Caligaris-Cappio; G Camussi; P Dellabona
Journal: Hum Immunol Date: 1985-10 Impact factor: 2.850

Review 2. Human natural killer cells: biologic and pathologic aspects.

Authors: G Trinchieri; B Perussia
Journal: Lab Invest Date: 1984-05 Impact factor: 5.662

3. Abnormal expansions of polyclonal large to small size granular lymphocytes: reactive or neoplastic process?

Authors: G Semenzato; G Pizzolo; A Ranucci; C Agostini; M Chilosi; I Quinti; G De Sanctis; B Vercelli; F Pandolfi
Journal: Blood Date: 1984-06 Impact factor: 22.113

4. A differentiation antigen of human NK and K cells identified by a monoclonal antibody (HNK-1).

Authors: T Abo; C M Balch
Journal: J Immunol Date: 1981-09 Impact factor: 5.422

5. Phenotypic and functional heterogeneity of human cloned natural killer cell lines.

Authors: T Hercend; E L Reinherz; S Meuer; S F Schlossman; J Ritz
Journal: Nature Date: 1983-01-13 Impact factor: 49.962

6. A monoclonal antibody reactive with human peripheral blood monocytes.

Authors: J Breard; E L Reinherz; P C Kung; G Goldstein; S F Schlossman
Journal: J Immunol Date: 1980-04 Impact factor: 5.422

7. Isolation of human NK cells by density gradient centrifugation.

Authors: T Timonen; E Saksela
Journal: J Immunol Methods Date: 1980 Impact factor: 2.303

8. Spontaneous release of a factor with properties of T cell growth factor from a continuous line of primate tumor T cells.

Authors: H Rabin; R F Hopkins; F W Ruscetti; R H Neubauer; R L Brown; T G Kawakami
Journal: J Immunol Date: 1981-11 Impact factor: 5.422

9. Antibody-dependent and -independent cytotoxicity of human mononuclear phagocytes: defective stimulation of tumoricidal activity in milk macrophages.

Authors: A Biondi; G Peri; N Colombo; G Bolis; A Mantovani
Journal: Clin Exp Immunol Date: 1982-09 Impact factor: 4.330

10. Evidence for the T3-associated 90K heterodimer as the T-cell antigen receptor.

Authors: S C Meuer; O Acuto; R E Hussey; J C Hodgdon; K A Fitzgerald; S F Schlossman; E L Reinherz
Journal: Nature Date: 1983-06-30 Impact factor: 49.962

15 in total

1. Large granular lymphocytosis associated with rheumatoid arthritis.

Authors: A Samanta; I Grant; F E Nichol; J H Pringle; J K Wood; A C Campbell
Journal: Ann Rheum Dis Date: 1988-10 Impact factor: 19.103

2. Routine diagnosis of large granular lymphocytic leukaemia by Southern blot and polymerase chain reaction analysis of clonal T cell receptor gene rearrangement.

Authors: D K Ryan; H D Alexander; T C Morris
Journal: Mol Pathol Date: 1997-04

3. Clonal T-cell populations in pityriasis lichenoides et varioliformis acuta (Mucha-Habermann disease).

Authors: L M Weiss; G S Wood; L W Ellisen; T C Reynolds; J Sklar
Journal: Am J Pathol Date: 1987-03 Impact factor: 4.307

4. Establishment of Tac-negative, interleukin-2-dependent cytotoxic cell lines from large granular lymphocytes (LGL) of patients with expanded LGL populations.

Authors: V Pistoia; A J Carroll; E F Prasthofer; A B Tilden; K S Zuckerman; M Ferrarini; C E Grossi
Journal: J Clin Immunol Date: 1986-11 Impact factor: 8.317

5. Inhibition of non-MHC-restricted cytotoxicity by CD45 but not CD3 monoclonal antibodies in patients with large granular lymphoproliferative disease.

Authors: G C Starling; S E Davidson; J C Nimmo; M E Beard; D N Hart
Journal: Clin Exp Immunol Date: 1989-12 Impact factor: 4.330

6. Immunoglobulin and T-cell receptor beta-chain gene rearrangement analysis of Hodgkin's disease: implications for lineage determination and differential diagnosis.

Authors: D M Knowles; A Neri; P G Pelicci; J S Burke; A Wu; C D Winberg; K Sheibani; R Dalla-Favera
Journal: Proc Natl Acad Sci U S A Date: 1986-10 Impact factor: 11.205

10. Clonal rearrangement for immunoglobulin and T-cell receptor genes in systemic Castleman's disease. Association with Epstein-Barr virus.

Authors: C A Hanson; G Frizzera; D F Patton; B A Peterson; K L McClain; K J Gajl-Peczalska; J H Kersey
Journal: Am J Pathol Date: 1988-04 Impact factor: 4.307