Literature DB >> 393429

Sequential chemotherapy and circadian rhythm in human solid tumours. A randomised trial.

C Focan.   

Abstract

Sixty-three patients were randomised into two groups each receiving the same 40-h sequential chemotherapy regimen (methotrexate or 5-FU, followed by vinblastine and cyclophosphamide). In the group receiving infusions of chemotherapeutic agents at times taking into account the circadian rhythm of tumoral proliferation, the antitumoral effectiveness appeared significantly better with respect to both tumoral regressions (85% contrasting with 58% in the other group) and the duration of response and survival.

Entities:  

Mesh：

Substances：

Year:  1979        PMID： 393429     DOI： 10.1007/bf00262422

Source DB:  PubMed          Journal:  Cancer Chemother Pharmacol        ISSN： 0344-5704            Impact factor:   3.333


  19 in total

1.  [Nycthemeral rhythm of division and synchronization-recruitment chemotherapy in clinical oncology].

Authors:  C Focan
Journal:  Rev Med Liege       Date:  1975-07-15

2.  [The 24 hour rhythm of mitotic frequency in malignant tumors].

Authors:  A VOUTILAINEN
Journal:  Acta Pathol Microbiol Scand Suppl       Date:  1953

3.  Twenty-four-hour variations in DNA synthesis of a fast-growing and a slow-growing hepatoma: DNA synthesis rhythm in hepatoma.

Authors:  R E Nash; J M Llanos
Journal:  J Natl Cancer Inst       Date:  1971-11       Impact factor: 13.506

4.  [Comparative study of circadian rhythms of mitotic activity in neoplastic and normal tissues].

Authors:  M V Berezkin
Journal:  Biull Eksp Biol Med       Date:  1970-10

5.  [Sequential chemotherapy based on the hypothesis of a circadian rhythm of tumor proliferation].

Authors:  C Focan
Journal:  Nouv Presse Med       Date:  1975-11-08

6.  [Demonstration of a nycthemeral rhythm of cell division in sarcomas induced by methylcholanthrene].

Authors:  C Focan; H Barbason; E H Betz
Journal:  C R Acad Hebd Seances Acad Sci D       Date:  1973-04-02

7.  Circadian rhythms in hairless mouse epidermal DNA-synthesis as measured by double labelling with H3-thymidine (H3Tdr.).

Authors:  E M Tvermyr
Journal:  Virchows Arch B Cell Pathol       Date:  1972

8.  Mitotic circadian rhythm in a fast-growing and a slow-growing hepatoma: mitotic rhythm in hepatomas.

Authors:  J M Echave Llanos; R E Nash
Journal:  J Natl Cancer Inst       Date:  1970-03       Impact factor: 13.506

9.  Use of synchronization induced by cyclophosphamide in a methylcholanthrene sarcoma with circadian proliferation to rational sequential chemotherapy.

Authors:  C Focan; H Barbason; E H Betz
Journal:  Biomedicine       Date:  1975-06-30

10.  Incorporation of tritiated thymidine into the skin and hair follicles. II. Daily fluctuations in 3 H-TdR and 3 H-UR levels.

Authors:  C S Potten; B A Jessup; M B Croxson
Journal:  Cell Tissue Kinet       Date:  1971-09
View more
  7 in total

1.  Fundamental pharmacokinetic limits on the utility of using a sinusoidal drug delivery system to enhance therapy.

Authors:  R R Burnette
Journal:  J Pharmacokinet Biopharm       Date:  1992-10

2.  Inclusion of vindesine in sequential chemotherapy based upon the circadian rhythm of human solid tumors.

Authors:  C Focan; S Le Hung; J J Claessens; H Debruyne
Journal:  J Cancer Res Clin Oncol       Date:  1979-09       Impact factor: 4.553

3.  The effect of timing of a single injection on the toxicity of methotrexate in the rat.

Authors:  J English; G W Aherne; V Marks
Journal:  Cancer Chemother Pharmacol       Date:  1982       Impact factor: 3.333

4.  Neurological toxicity of vindesine used in combination chemotherapy of 51 human solid tumors.

Authors:  C Focan; R Olivier; S Le Hung; R Bays; J J Claessens; H Debruyne
Journal:  Cancer Chemother Pharmacol       Date:  1981       Impact factor: 3.333

5.  The Genomic Landscape and Pharmacogenomic Interactions of Clock Genes in Cancer Chronotherapy.

Authors:  Youqiong Ye; Yu Xiang; Fatma Muge Ozguc; Yoonjin Kim; Chun-Jie Liu; Peter K Park; Qingsong Hu; Lixia Diao; Yanyan Lou; Chunru Lin; An-Yuan Guo; Bingying Zhou; Li Wang; Zheng Chen; Joseph S Takahashi; Gordon B Mills; Seung-Hee Yoo; Leng Han
Journal:  Cell Syst       Date:  2018-03-07       Impact factor: 10.304

Review 6.  Circadian Variation in Efficacy of Medications.

Authors:  James C Walton; William H Walker; Jacob R Bumgarner; O Hecmarie Meléndez-Fernández; Jennifer A Liu; Heather L Hughes; Alexis L Kaper; Randy J Nelson
Journal:  Clin Pharmacol Ther       Date:  2020-11-29       Impact factor: 6.903

7.  Implications of Circadian Rhythm Regulation by microRNAs in Colorectal Cancer.

Authors:  Song Wu; Andrew Fesler; Jingfang Ju
Journal:  Cancer Transl Med       Date:  2016-02-28
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.